In a study carried out by a group of Spanish and German scientists a new protein complex that plays an important role in the orchestration of the above-mentioned processes has been discovered. This complex demonstrates the existence of a new control mechanism in the cellular movements involved in the early development (gastrulation).
As an innovative feature, this study, that will be published next Friday, 19th January, at the prestigious scientific journal Science, has used the computer design “in silico” to direct the experimental work, developed by the research group of the Spanish scientist Luis Serrano. This has allowed avoiding the tedious lab trials that, in many cases, don’t lead anywhere and/or are redundant. Particularly, the use of protein design software and structural information has allowed sifting the genome of the vinegar fly (Drosophila) and predicting the interaction of two proteins (T48 y RhoGEF2).
The use of protein design software to predict the protein-protein or protein-DNA interaction opens de door to discovering other protein-protein interactions and, the most important aspect for human health, predicting the functional effect of variations in the human genome with implications in the customized medicine.
As for the identification of a new regulation pathway of the gastrulation process in the development of the vinegar fly, it will allow to look for similar mechanisms in human individuals that might be involved in embryonic malformations related to cellular migratory processes.
The study has been directed by Maria Leptin, from the University of Cologne, in Germany. The design and prediction aspects have been developed by the Spanish scientists Luis Serrano, who has just left the leadership of the Structural and Computational Biology programme at the European Molecular Biology Laboratory (EMBL) to lead the Systems Biology programme at the Centre for Genomic Regulation, in Barcelona, and Gregorio Fernández, from the Cellular and Molecular Biology Institute, of the University Miguel Hernández, in Elche.
Gloria Lligadas | alfa
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Life Sciences
17.08.2018 | Event News
17.08.2018 | Materials Sciences