Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovered A New Protein Complex That Plays An Important Role In Organ Formation, Cellular Development And Cicatrisation Process

19.01.2007
Cellular movements are essential in organ formation processes, in cellular development and cicatrisation processes. These processes are directed and orchestrated by the formation of specific protein complexes translating information coming from cellular contacts.

In a study carried out by a group of Spanish and German scientists a new protein complex that plays an important role in the orchestration of the above-mentioned processes has been discovered. This complex demonstrates the existence of a new control mechanism in the cellular movements involved in the early development (gastrulation).

As an innovative feature, this study, that will be published next Friday, 19th January, at the prestigious scientific journal Science, has used the computer design “in silico” to direct the experimental work, developed by the research group of the Spanish scientist Luis Serrano. This has allowed avoiding the tedious lab trials that, in many cases, don’t lead anywhere and/or are redundant. Particularly, the use of protein design software and structural information has allowed sifting the genome of the vinegar fly (Drosophila) and predicting the interaction of two proteins (T48 y RhoGEF2).

The use of protein design software to predict the protein-protein or protein-DNA interaction opens de door to discovering other protein-protein interactions and, the most important aspect for human health, predicting the functional effect of variations in the human genome with implications in the customized medicine.

As for the identification of a new regulation pathway of the gastrulation process in the development of the vinegar fly, it will allow to look for similar mechanisms in human individuals that might be involved in embryonic malformations related to cellular migratory processes.

The study has been directed by Maria Leptin, from the University of Cologne, in Germany. The design and prediction aspects have been developed by the Spanish scientists Luis Serrano, who has just left the leadership of the Structural and Computational Biology programme at the European Molecular Biology Laboratory (EMBL) to lead the Systems Biology programme at the Centre for Genomic Regulation, in Barcelona, and Gregorio Fernández, from the Cellular and Molecular Biology Institute, of the University Miguel Hernández, in Elche.

Gloria Lligadas | alfa
Further information:
http://www.crg.es

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Quantum material is promising 'ion conductor' for research, new technologies

17.08.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>