Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Men with no sons more at risk for prostate cancer

08.01.2007
Cutting edge program examines men's reproductive health and role of fathers in risk for developmental disorders among offspring

In a new and unique study to determine if genes on the Y chromosome are involved in prostate cancer, researchers at Columbia University's Mailman School of Public Health in conjunction with Hebrew University of Jerusalem found that men who had only daughters had a higher risk of prostate cancer than men who had at least one son, thus signifying a possible defect on the father's Y chromosome. The results, published in the January 3, 2007 issue of the Journal of the National Cancer Institute, further indicate that the relative risk of prostate cancer decreases as the number of sons increases.

The researchers in the Mailman School's Department of Epidemiology analyzed the relative risk of prostate cancer by the sex of offspring among fathers registered in a family-based research cohort in Israel. From this cohort of 38,934 men, followed from the birth of their offspring (in 1964 through 1976) until 2005, the authors conclude that genes on the Y chromosome may be involved in prostate cancer risk in this population.

"We surveyed vital status and cancer incidence, and found a strong trend for a decrease in prostate cancer risk as the number of sons increased," said Susan Harlap, MD, professor of clinical Epidemiology at the Mailman School of Public Health, and the leader of the research team. "We anticipate that this finding will have a significant impact on the direction of research in this field going forward." Overall, there was a 40% increase in prostate cancer in men lacking sons.

The offspring's sex depends on whether it receives an X or a Y chromosome from the father. A man with a damaged Y chromosome will be less likely to have sons and those with a damaged X chromosome may be unable to sire daughters. "Our findings suggest that the biological significance of lack of sons – whatever it is that leads to increased risk of prostate cancer - becomes increasingly important as family size increases," observes Dr. Harlap. "Overall, our findings are consistent with hypotheses that tie Y chromosome loci to prostate cancer, although other explanations cannot be excluded," implies Dr. Harlap.

The researchers also looked at men lacking daughters. For example, in men with exactly two offspring, those with no daughters had an 11% increase in the incidence of prostate cancer, and those with no sons had a 47% increase, compared with men who had one son and one daughter. "The increased risk of prostate cancer in men with no daughters is probably due to chance," says Dr. Harlap, "but it might indicate a problem with a gene on the X-chromosome."

In addition to the Columbia University Mailman School of Public Health and Columbia University Department of Psychiatry, the international team of scientists included researchers from Hebrew University-Hadassah School of Public Health and the Braun School of Public Health, Jerusalem, Israel.

The Jerusalem Perinatal Cohort is among those being followed by the life course studies program within the Mailman School's Department of Epidemiology. Department Chair Ezra Susser, MD, DrPH, has been building a program of life course research -- called the Imprints Center -- in which epidemiologists seek to uncover the causes of a broad range of disease and health outcomes, by following individuals from an early point in life and examining their risks for disease. Life course studies are particularly well positioned to examine the interplay of genetic and environmental risk factors - the key to understanding many complex diseases.

Stephanie Berger | EurekAlert!
Further information:
http://www.columbia.edu

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Air pollution leads to cardiovascular diseases

21.08.2018 | Ecology, The Environment and Conservation

Researchers target protein that protects bacteria's DNA 'recipes'

21.08.2018 | Life Sciences

A paper battery powered by bacteria

21.08.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>