Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Racial disparity in breast cancer outcome linked to aggressive tumors

24.10.2006
Malignancies of the breast can be more aggressive and associated with poorer outcome in African-Americans than other races, according to a new study.

Published in the December 1, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study reviewed patient data from two different clinical trial protocols – to control for healthcare access biases – and found that African-Americans have tumors with poorer prognostic cellular characteristics and more aggressive clinical presentations, pointing to the possibility that racially influenced tumor biology may contribute to observed racial disparities in breast cancer outcome.

Population-based studies have demonstrated significant differences in breast cancer survival rates based on race, particularly among African-Americans who are more likely to die of their disease than Caucasians. However, other races have been poorly studied. An often hypothesized explanation is socioeconomic differences that impact healthcare and access. Recent data suggest, however, that there may be differences in the tumors at the cellular level that may contribute to poor clinical presentations and outcomes.

Led by Wendy A. Woodward, M.D. of the University of Texas M. D. Anderson Cancer Center in Houston, researchers reviewed medical records and outcome data from 2,140 Caucasian, Hispanic and African-American breast cancer patients enrolled in clinical trials, controlling for differences in treatment that compromise other studies. Patients were either treated with chemotherapy before (neoadjuvant) or after (adjuvant) mastectomy.

The researchers found that in both treatment groups African-American race was independently associated with poor tumor and clinical characteristics and low survival rates compared to both Caucasian-Hispanic cohorts. For example, African-Americans presented with more advanced disease and were likely to have estrogen-receptor negative tumors. Analysis to control for other confounding factors confirmed that African-American race by itself was associated with lower survival in both treatment groups.

This study, conclude the authors, supports previous data "that African-American women more frequently had ER-negative disease and high-grade tumors and that African-American race was associated with a poorer survival rate." This was confirmed in "two independent data sets of patients treated on prospective protocols."

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com
http://www.interscience.wiley.com/cancer-newsroom

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Quantum bugs, meet your new swatter

20.08.2018 | Information Technology

A novel synthetic antibody enables conditional “protein knockdown” in vertebrates

20.08.2018 | Life Sciences

Metamolds: Molding a mold

20.08.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>