Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dartmouth researchers find key player in immune system regulation

28.08.2006
Studies led by Dartmouth Medical School researchers have revealed a crucial link in how the immune system works. In a study published online on August 20 in the journal Nature, the researchers found that mast cells, known for their role in allergy reactions such as watery eyes and runny noses, are connected to the activity of regulatory T cells, which suppress immune responses. The researchers say theirs is the first study to find that mast cells mediate immune system suppression.

"Our finding is a complete surprise. We were studying transplant tolerance and what's required to protect a graft from rejection," says Randolph Noelle, professor of microbiology and immunology at Dartmouth Medical School. "When we went looking to see what genes were responsible in a successful graft, we found high levels of mast cell gene products, which made the connection between regulatory T cells and mast cell recruitment. The fact that mast cells may be instrumental in orchestrating regulatory T cell tolerance was new, unanticipated, and surprising."

In their study, the researchers determined that mast cells are crucial for sustaining immune suppression in transplanted skin on mice, which means longer acceptance or tolerance of the transplant. Mice that were mast cell deficient rejected the skin graft. Furthermore, the researchers found that IL-9, a protein already known for playing a role in mast cell activation and recruitment, was discovered to be produced by regulatory T cells. As such, the other key discovery in this study was that Il-9 appears to be an essential ingredient in the success of transplanted skin.

"Because of this study, mast cells are now the new cellular target in understanding immune suppression," says Noelle, who is co-director of the Immunotherapy Program of the Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center. "We now have a whole new set of cellular, and eventually molecular, interactions to study."

According to Noelle, the findings might also impact some cancer treatments as mast cells are known to promote growth in some tumors. Future research might look into suppressing mast cells to boost the immune system, which could lead to tumor rejection.

"It is only because of the extremely high quality of the graduate students in Dartmouth's Molecular and Cell Biology Program and the hard work of post-docs and colleagues that this new paradigm of cellular interactions in immunology was discovered," says Noelle.

Collaborating researchers on this study include Li-Fan Lu, Evan Lind, David Gondek, Kathy Bennett, Michael Gleeson, Karina Pino-Lagos, and Zachary Scott, all at Dartmouth; Anthony Coyle and Jennifer Reed at MedImmune in Gaithersburg, Md.; Jacques Van Snick at the Ludwig Institute for Cancer Research at the University of Louvain in Brussels, Belgium; and Terry Strom and Xin Zheng at Beth Israel Deaconess Medical Center in Boston, Mass.

Noelle's research is funded by the National Institutes of Health.

Sue Knapp | EurekAlert!
Further information:
http://www.Dartmouth.edu

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>