Prof. Maksymowych, Division of Rheumatology, University of Alberta, Edmonton, Canada, and his radiologist colleagues recognized the importance of image-guided IA steroid placement for accurate treatment and the significant effects this might have on the clinical responses in an earlier trial showing that the treatment was not effective. Precision image-guided injections can be very helpful and at times are essential to help localize the structural origin of a patient’s pain, especially in places where it might be difficult to detect the pain source, such as in the hip and the spine.
OA is the most common type of arthritis affects approximately 2.95 women per 1000 population and approximately 1.71 men per 1000 population.2 The typical symptoms of hip OA are stiffness, as well as pain, which is usually felt in the groin, but may radiate to the knee, buttock, or inner thigh, and is mainly felt on weight-bearing and aggravated by movement. Over time, the patient might get increased stiffness and might find it difficult to reach down to tie shoe laces, or put on socks and shoes. The functional ability may also progress to difficulties in rising from a chair, using stairs, walking and dressing.
The 52 patients enrolled in the trial, received fluoroscopically guided IA injection and were randomly allocated placebo (2 ml of normal saline) or 40 mg of the treatment (triamcinolone hexacetonide). Assessments were performed at baseline, one and two months post-injection. The study found that the patients given steroids improved significantly compared to placebo in all primary and secondary endpoints; pain, stiffness, physical function and global assessment, after 2 months.
“This is very encouraging data, which I believe will have a great response in the medical community. Because there is no cure, the therapeutic goal of treatment for osteoarthritis is to minimize the effects of the disease and its consequences over time. The study shows that the treatment with steroids offers many patients with late stage OA some hope of pain relief when conservative therapy has failed”, said Prof. Maksymowych.
Mia Gannedahl | alfa
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
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Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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