Findings help researchers revise models of mammalian sense of smell
Composite of olfactory neuron response to lyral odor. The background shows intact olfactory neuroepithelium containing MOR23 cells tagged with GFP (green fluorescent protein). The right upper corner shows dendritic knob and cilia from a single MOR23 neuron. The left lower corner shows the electrical responses over time of a single MOR23 cell to lyral, the ligand for MOR23, at different concentrations. (Credit: Xavier Grosmaitre and Minghong Ma, PhD, University of Pennsylvania School of Medicine)
In a mouse model, University of Pennsylvania School of Medicine researchers discovered that olfactory sensory neurons expressing the same receptor responded to a specific odor with an array of speeds and sensitivities, a phenomenon previously not detected in the mammalian sense of smell. The group published their findings this week in the online edition of the Proceedings of the National Academy of Sciences.
"We assumed that the sensory neurons that express the same receptor would respond to a specific odor in the same way," says senior author Minghong Ma, PhD, Assistant Professor of Neuroscience at Penn. "But in real biology, these olfactory neurons keep regenerating, and even though they all express the same receptor, theyre probably at different states of maturation, displaying different qualities. By knowing that olfactory neurons can respond differently, were adding another layer to understanding how the olfactory system receives outside information."
Karen Kreeger | EurekAlert!
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences