An inflamed injury may increase levels of a protein responsible for persistent pain, causing the brain to mimic pain long after source has disappeared, says U of T researchers. The findings could have serious implications for the millions of Canadians who suffer from chronic pain.
The study, published in the current issue of the Journal of Neuroscience, shows how inflammation in mice increases NR2B proteins – proteins that facilitate nerve cell communication – and imprint a painful response in brain even after the stimulus is removed. "What were interested in uncovering are the molecular mechanisms that can turn early pain into persistent pain," says Professor Min Zhuo of physiology, EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health and lead author of the study. "We believe that the bodys inflammatory response helps to etch the initial pain into our memory."
Normally when a mouse or a person experiences a painful event, receptors in the injury site send an electrical impulse up the spine and to the brain. The signal triggers receptors called glutamate AMPA and kainate, which flare up initially but do not directly alter the physiology of the cells. When the painful event also triggers inflammation, the nerves send extra information to the normally dormant NR2B receptors – receptors that receive messages and then produce physiological effects in the cell.
Karen Kelly | EurekAlert!
Drought hits rivers first and more strongly than agriculture
06.09.2018 | Max-Planck-Institut für Biogeochemie
Landslides triggered by human activity on the rise
23.08.2018 | European Geosciences Union
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
New measurement method allows researchers to precisely follow the movement of individual molecules over long periods of time
The function of proteins – the molecular tools of the cell – is governed by the interplay of their structure and dynamics. Advances in electron microscopy have...
16.10.2018 | Event News
02.10.2018 | Event News
01.10.2018 | Event News
16.10.2018 | Life Sciences
16.10.2018 | Physics and Astronomy
16.10.2018 | Event News