Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemotherapy errors rare, but have potential for serious consequences

25.10.2005


About one out of 30 chemotherapy orders at three ambulatory infusion clinics had errors, and one in 50 orders had a serious error, according to a study appearing in the December 1, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study, performed at the Dana-Farber Cancer Institute, found most but not all errors were detected before they reached the patient. None was life-threatening or caused patient harm. Still, an accompanying editorial says the study underscores the need to implement safer controls of drug ordering and dispensing at chemotherapy infusion clinics.

Medication errors in hospitals are a stark reminder of the potential harm that can occur when patients are admitted to the hospital. While most medications are well tolerated, a few classes are toxic and require complex dosing regimens, such as those used in chemotherapy. Even a low error rate from these medications could potentially lead to significant harm, including death.

Aside from a few case reports in journals and popular media, little research has investigated the error rate of chemotherapy orders at outpatient clinics or hospitals. Some individual institutions that have been affected by these reported errors, such as the Dana-Farber Cancer Institute (a member of the Dana-Farber/Harvard Cancer Center, a National Cancer Institute-designated comprehensive cancer center), have made extensive changes to prevent such errors, such as computerization of the medication ordering system.



Led by Tejal K. Gandhi, M.D., M.P.H. and Sylvia B. Bartel, R.Ph., M.H.P., researchers from the Brigham and Women’s Hospital, the Dana-Farber Cancer Institute, and the Harvard School of Public Health reviewed over 10,100 medication orders from one pediatric and two adult ambulatory clinics, which used either a paper or computerized medication ordering system.

The researchers used a strict definition of error and counted any mistake in the medication process, including ordering, dispensing, transcribing, administering, and monitoring.

The review of orders demonstrated an overall medication error rate of three percent and a serious error rate of two percent, less than the five percent rate on all orders identified in previous studies. Categorized according to the severity of the error, 82 percent of the errors in adults and 60 percent in children had the potential to cause an adverse drug event (ADE) had they reached a patient. Of these, approximately 33 percent could have caused serious harm. Nearly half were intercepted by existing systemic checks before they reached the patient and none actually caused an ADE.

In the adult clinics, which used a computerized ordering system, the most frequent errors were due to omission of dosages and orders not being discontinued. In the pediatric clinic, which used a paper-based ordering system, the most frequent errors were due to orders not being discontinued and incorrect dosages.

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com
http://www.interscience.wiley.com/cancer-newsroom

More articles from Studies and Analyses:

nachricht Some brain tumors may respond to immunotherapy, new study suggests
11.12.2018 | Columbia University Irving Medical Center

nachricht Climate change and air pollution damaging health and causing millions of premature deaths
30.11.2018 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>