A new study concludes that widespread screening for cardiovascular risk by measuring blood levels of C-reactive protein (CRP), a protein produced by the liver, should not be advocated. Researchers at the University of Maryland School of Medicine in Baltimore analyzed data from more than 15,000 adult men and women and found that CRP appears to be tightly linked to traditional risk factors for heart disease rather than being an independent risk factor. The study is published in the October 10, 2005, Archives of Internal Medicine.
C-reactive protein (CRP) is released by the liver in response to inflammation related to an infection, injury, or conditions such as arthritis. Inflammation also has been associated with the cause and progression of cardiovascular disease, particularly in the build up of fatty deposits in the lining of arteries.
The researchers found that elevated CRP goes hand in hand with traditional risk factors for heart disease, such as smoking, obesity, high blood pressure or elevated cholesterol, and rarely occurs in their absence. CRP levels are defined as normal (less than 1 milligram per liter (mg/L), borderline-high (1-3 mg/L) and high (greater than 3 mg/L).
Bill Seiler | EurekAlert!
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