University of Pittsburgh study results published in Archives of General Psychiatry
A treatment program that stresses maintaining a regular schedule of daily activities and stability in personal relationships is an effective therapy for bipolar disorder, report University of Pittsburgh School of Medicine researchers in Septembers Archives of General Psychiatry. Interpersonal and Social Rhythm Therapy (IPSRT), a novel approach developed by the University of Pittsburgh researchers, was effective in preventing relapse over a two-year period, particularly in patients who dont have other chronic medical problems such as diabetes or heart disease.
IPSRT is based on the idea that disruptions in daily routines and problems in interpersonal relationships can cause recurrence of the manic and depressive episodes that characterize bipolar disorder. During the treatment, therapists help patients understand how changes in daily routines and the quality of their social relationships and their social roles, such as a parent, spouse or caregiver, for example, can affect their moods. After identifying situations that can trigger mania or depression, therapists teach the individuals how to better manage stressful events and better maintain positive relationships.
Jocelyn Uhl | EurekAlert!
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
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