Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer patients have increased risk of cognitive dysfunction

01.06.2005


Cancer patients may have an increased risk of cognitive dysfunction compared with individuals who have never had cancer, according to a new study in the June 1 issue of the Journal of the National Cancer Institute.



Research has documented that cancer patients can exhibit cognitive deficits that persist even at 5 years after treatment. However, how long these cognitive deficits last or whether they worsen and become more apparent in older age--when the risk for cognitive dysfunction is higher--is not known.

To determine the extent of cognitive deficits in cancer patients, Beth E. Meyerowitz, Ph.D., of the University of Southern California in Los Angeles, and colleagues conducted a study of 702 cancer survivors from Sweden and their cancer-free twins using data collected through the Karolinska Institute.


All cancer survivors and those who had survived cancer for 5 or more years were twice as likely as their cancer-free twins to have cognitive dysfunction. (Cognitive function was assessed using a structured telephone interview.) Cancer survivors were also twice as likely to be diagnosed with dementia, but this result was not statistically significant. The authors conclude that cancer patients have an increased risk for long-term cognitive dysfunction compared with individuals who have never had cancer.

"Our data suggest that cancer and its treatments may lower survivors’ cognitive reserve and thus increase their long-term risk of cognitive dysfunction and dementia, a serious clinical concern for physicians treating cancer survivors," the authors write. "Further research should identify mechanisms that mediate the relationship between cancer and cognitive dysfunction and explore whether specific treatments are associated with long-term cognitive effects. This knowledge will help health care providers and patients make informed decisions about treatments."

In an editorial, Jeffrey S. Wefel, Ph.D., and Christina A. Meyers, Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, urge caution when interpreting the results the this study. "Recent studies have demonstrated that cognitive dysfunction may be present before treatment, may worsen acutely secondary to treatment-related neurotoxicity, and may continue after cessation of therapy," they write. They call for more studies to determine which treatment regimens are the most neurotoxic, how and which cognitive and behavioral domains are most affected, and the risk factors for this neurotoxicity.

Sarah L. Zielinski | EurekAlert!
Further information:
http://www.oupjournals.org

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>