Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research shows smoking adds a decade to reproductive age of IVF patients

07.04.2005


A major new Dutch study has found that smoking adds the equivalent of ten years to a 20-year-old subfertile woman’s reproductive age and has a "devastating" impact on a couples’ chances of having a live birth after IVF. Being overweight also seriously damages their chances.

The harmful effects of smoking or being overweight were strongest among those women who had no obvious cause for not conceiving, according to the research, published today (Thursday 7 April) in Europe’s leading reproductive medicine journal Human Reproduction[1].

Lead researcher Dr Bea Lintsen, from Radboud University Nijmegen Medical Centre, said: "The positive news from our results, however, is that they suggest that couples – in particular, women with unexplained subfertility – may be able to improve the success of IVF treatment by quitting smoking and losing weight."



The research was a collaboration by doctors from twelve centres in the Netherlands who drew on data from a proportion of patients involved in the nation-wide OMEGA study, which was begun in 1995 to examine late effects of hormone stimulation. The team investigated the success rate of the first cycle of treatment in 8,457 women, analysing information on reproduction and lifestyle factors, combined with medical records of IVF treatment from 1983 to 1995. ICSI cycles were not evaluated as the treatment was not common during that period.

They divided the cause of subfertility into four categories – fallopian tube problems, male subfertility, unexplained fertility, and other causes (mainly women with polycystic ovarian syndrome or endometriosis) – and analysed first cycle treatment results for the first three causes. Of the total, 1,828 of the first IVF treatment cycles were for unexplained subfertility.

The overall live birth rate per cycle was 15.2%[2]. It was highest at 17.8% in couples with unexplained subfertility. Women with tubal problems had a 14.6% rate and the lowest success rate was for those with male subfertility (13.6%).

More than 40% of the women were smokers at the time of undergoing their first attempt at IVF and more than 7% were overweight i.e. had a body mass of 27kg/m2 or more.

Older women had lower success rates no matter what was the cause of subfertility, with the live birth rate decreasing by 2% for each additional year of age. "In all subgroups smokers had a lower delivery rate per treatment cycle than non-smokers," Dr Lintsen said. "The live birth rate for smokers was 28% lower than that of non-smokers. This was most marked in women who had no known cause for subfertility where the live birth rate among smokers was only 13% compared to 20% for non-smokers."

The miscarriage rate per pregnancy was also significantly higher for women who smoked, with around 21% losing their babies compared with around 16% of non-smokers.

Overweight women also fared badly with a 33% lower chance of a live birth from their first treatment cycle. As with smoking, the unfavourable effect of overweight was largest in women with unexplained subfertility. Only 14% had a live baby compared with over 18% for normal weight and nearly 21% for slightly overweight women.

Professor Didi Braat, one of the co-authors, said: "What our research clearly shows is that both smoking and being overweight unfavourably affect the live birth rate after IVF. Smoking has a devastating impact. It is comparable to adding a decade to the reproductive age of a 20-year-old. This means it makes her the equivalent of a 30-year-old non-smoker in reproductive terms.

"However, it also indicates that subfertile couples may help their chances of successful treatment by life-style changes. As the effects of smoking and overweight were greatest among women with unexplained subfertility, these results suggest that this group in particular may be able to improve the outcome of subfertility treatment by quitting smoking and losing weight."

[1] Effects of subfertility cause, smoking and body weight on the success rate of IVF. Human Reproduction. Doi:10.1093/humrep/deh898

[2] The authors point out that the success rates from this data might differ from success rates today, as success rates have increased since 1995 when the OMEGA study began.

Emma Mason | EurekAlert!
Further information:
http://www.eshre.com

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>