The multiple “litter” births of mice, versus the normal singleton pregnancy of humans, is due to defective processing in mice of a common mammalian protein called bone morphogenetic protein 15 (BMP-15), according to new study by University of California, San Diego (UCSD) School of Medicine researchers.
Published online the week of April 4, 2005 in Proceedings of the National Academy of Sciences, and appearing in the journal’s April 12, 2005 print edition, the study provides one of the first insights into the physiological mechanisms responsible for multiple births and suggests a potential therapeutic target for infertility and contraception.
“Infertility is a major problem for many couples,” said the study’s senior author, Shunichi Shimasaki, Ph.D., UCSD professor of reproductive medicine. “Based on our findings, it is possible that therapeutic regimens targeting BMP-15 could offer exciting new opportunities for novel treatments for female infertility. On the other side of the coin, BMP-15 could also serve as a new target for non-steroidal contraceptives.”
Sue Pondrom | EurekAlert!
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences