In the largest and most comprehensive prospective study of its kind, researchers at The University of Texas M. D. Anderson Cancer Center have concluded that the risk of ischemic heart disease and, ultimately, cardiac death following radiation treatment for breast cancer has steadily declined over the last quarter century, according to a new study published in the March 16 issue of the Journal of the National Cancer Institute.
This study offers scientific evidence to what was long thought to be true but never proven: that improvements in radiation techniques and delivery have greatly impacted radiation-associated cardiac mortality. "For a while now, physicians have been telling women that receiving radiation for breast cancer is so much safer today than it was before. People believed it, but there really was very little scientific evidence or studies examining the relationship between advancements in radiation therapy to ischemic heart disease," says Sharon Giordano, M.D., the studys lead author and an assistant professor in M. D. Andersons Department of Breast Medical Oncology. "Before now, there were no studies that looked at the effects of radiation to the heart over time. Most previous analyses had involved women who had been treated in the 1950s, 1960s and 1970s, decades not considered in the era of modern medicine. "Comparing women with breast cancer on the left side where the heart is located (therefore, more radiation is delivered to the heart) versus those with disease on the right side gave us a perfect study to examine radiation-induced toxicity to the heart and cardiac mortality," she continues.
Giordano and her colleagues used information from the National Cancer Institute SEER database (Surveillance, Epidemiology, and End Results), the authoritative source of information on cancer incidence and survival in the United States. The researchers analyzed SEER data from 1973 to 1989 on 27,283 women - 13,998 had left-sided breast cancer, 13,285 had right-sided breast cancer. Patients were stratified into three cohorts by date diagnosed - 1973 to 1979, 1980 to 1984 and 1985 to 1989. Mortality from ischemic heart disease, heart problems caused by narrowing of the arteries, was compared in the three cohorts.
Laura Sussman | EurekAlert!
Some brain tumors may respond to immunotherapy, new study suggests
11.12.2018 | Columbia University Irving Medical Center
Climate change and air pollution damaging health and causing millions of premature deaths
30.11.2018 | International Institute for Applied Systems Analysis (IIASA)
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
14.12.2018 | Power and Electrical Engineering
14.12.2018 | Physics and Astronomy
14.12.2018 | Physics and Astronomy