Researchers have shown a correlation between fast food, weight gain, and insulin resistance in what appears to be the first long-term study on this subject. The Coronary Artery Risk Development in Young Adults (CARDIA) study by Mark Pereira, Ph.D., assistant professor in epidemiology, University of Minnesota School of Public Health, and David Ludwig, M.D., Ph.D., director of the Obesity Program at Childrens Hospital Boston, reported that fast food increases the risk of obesity and type 2 diabetes. The results of this 15-year study will be published in the Jan. 1 issue of The Lancet.
Participants who consumed fast food two or more times a week gained approximately 10 more pounds and had twice as great increase in insulin resistance in the 15-year period than participants who consumed fast food less than once per week.
"Fast-food consumption has increased in the United States during the past three decades," said Pereira. "While there have been many discussions about fast-foods effects on obesity, this appears to be the first scientific, comprehensive long-term study to show a strong connection between fast-food consumption, obesity, and risk for type 2 diabetes."
Jonell Rusinko | EurekAlert!
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
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