Trial results presented at the Annual American Society of Hematology Conference
University of Minnesota researchers will present the promising results from adult umbilical cord blood studies for patients with cancers of the blood and bone marrow. These studies’ findings provide solutions to the problems outlined in recently published studies in the New England Journal of Medicine (NEJM). "The results of our studies are a triumph in a treatment that has been largely viewed as only possible in children and adolescents," said John Wagner, M.D., professor of pediatrics and scientific director of clinical research, Blood and Marrow Transplantation Program and Stem Cell Institute.
A major limitation of adult cord blood transplantation highlighted in the NEJM articles is the high likelihood of patients dying early after transplant. This likelihood is due to: poor recovery of the patient’s blood cell counts as a result of the relatively low number of cells in cord blood compared to bone marrow, or toxicity from the high doses of chemotherapy and radiation used in conventional transplant regimens.
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A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
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