Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Doctors transplant ovary to woman’s arm to preserve fertility

08.11.2004


A new study finds surgery to transplant an ovary to the upper arm is feasible and preserves hormonal function in women undergoing treatment for cervical cancer. The report details the technical procedure and outcome of only the second successful human ovarian autotransplantation in the world. The study will be published in the December 15, 2004 issue of CANCER, a peer-reviewed journal of the American Cancer Society. A free abstract of this study will be available via the CANCER News Room upon online publication.



While treatment for cervical cancer, including systemic chemotherapy and regional administration of ionizing radiation, improves survival and cure rates, it can also cause permanent ovarian failure. Since cervical cancer is diagnosed during reproductive years, ovarian failure can be a severe blow to a patient’s quality of life. While protecting a patient’s fertility has often been studied, there have been no effective options.

Hormonal regulators, such as gonadotropin-releasing hormone, have demonstrated ovarian protection in rats but conflicting data in nonhuman primates. Cryopreservation of embryos has been successful, but there have been no reported successful cryopreservation and transplantation of oocytes or primordial follicles, which are necessary for future fertility. Attempts at ovarian tissue autograft or xenograft without blood vessel anastamoses in animal models and human cases have been promising but hampered by large follicle loss due to ischemia. However, animal models with anastamoses have demonstrated success, but there has been only one prior successful human autotransplant.


In this second successful human trial, C. Hilders, M.D., Ph.D., and a gynecologic surgical team of the Leiden University Hospital, The Netherlands developed a new method of ovarian autotransplantation to preserve ovarian function in a woman treated for cervical cancer. This method does not require developing a donor site with an implant over several months and utilizes a donor site that is easily accessible to noninvasive monitoring and has suitable vasculature.

Autotransplantation of a healthy ovary into the upper arm using brachial vessels to establish blood supply resulted in a functional ovary. Blood flow to and from the ovary was adequate to maintain cyclical follicular growth as verified by ultrasound and clinical examination. Moreover, the surgery did not result in additional operating time.

The authors conclude, "it seems likely that ovarian autotransplantation will be a realistic goal to achieve for women facing cancer, treated by high dose pelvic radiation, to preserve reproductive and hormonal function, thereby substantially improving the quality of life post-treatment."

Amy Molnar | EurekAlert!
Further information:
http://www.interscience.wiley.com/cancer-newsroom
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Some brain tumors may respond to immunotherapy, new study suggests
11.12.2018 | Columbia University Irving Medical Center

nachricht Climate change and air pollution damaging health and causing millions of premature deaths
30.11.2018 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Magic number colloidal clusters

13.12.2018 | Life Sciences

UNLV study unlocks clues to how planets form

13.12.2018 | Physics and Astronomy

Live from the ocean research vessel Atlantis

13.12.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>