Overactivity of protein kinase C (PKC), an enzyme that is implicated in bipolar disorder and schizophrenia, markedly impairs higher brain functions in animals, according to a Yale study published Oct. 29 in Science.
The research adds to mounting evidence that excessive activity of PKC may underlie the distractibility, impaired judgment, impulsivity, and disturbed thinking seen in bipolar disorder (also known as manic depressive illness), and in schizophrenia.
The study also shows that exposure to mild stress can activate PKC, which may lead to worsening of symptoms in patients with these disorders. The findings may explain how upsetting events in the environment can lead to deterioration in higher brain function, and why patients with schizophrenia or bipolar disorder may be particularly susceptible to stress-induced dysfunction. PKC inhibitors may be useful in treating these illnesses, according to Amy Arnsten, associate professor, Department of Neurobiology at Yale School of Medicine and senior author of the study.
Jacqueline Weaver | EurekAlert!
New study first to predict which oil and gas wells are leaking methane
21.12.2018 | University of Vermont
Droughts boost emissions as hydropower dries up
21.12.2018 | Stanford's School of Earth, Energy & Environmental Sciences
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
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