Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer drug may reduce kidney disease in lupus

08.09.2004


A drug that is already being tested as an anticancer agent, especially in lymphoma, may also reduce the kidney disease that is a result of systemic lupus, according to a researcher at Wake Forest University Baptist Medical Center.



The drug, SAHA (suberoylanilide hydroxamic acid ), inhibited the onset of lupus-related kidney disease in mice with lupus, said Nilamadhab Mishra, M.D., an assistant professor of internal medicine - rheumatology, writing in the Sept. 15 issue of The Journal of Immunology, published online today.

Systemic lupus affects an estimated 1.5 million Americans, mostly women, and about half have kidney damage. In systemic lupus, the normally protective immune system attacks the body’s own organs, damaging kidneys, heart, lungs, brain, blood or skin. Most people with lupus have achy or swollen joints, frequent fevers and prolonged or extreme fatigue.


Besides preventing kidney disease, SAHA decreased the size of the spleen in the mice and at the same time decreased the production of certain T-cells (a type of white blood cell) that are a key to the autoimmune disorder, when compared to mice with lupus that didn’t get the drug. It also decreased excess protein in the urine in the mice.

"Further studies are needed to delineate the most effective therapeutic regimen," Mishra and seven colleagues reported in the article. They also need to determine "the precise mechanisms of the anti-inflammatory properties of SAHA in lupus."

The mice in the study have a defective gene and spontaneously develop lupus, including lymph node swelling and increased spleen size, said Mishra.

The researchers reported that SAHA caused no adverse effects in the animals at the doses given.

Mishra said he hoped to start a phase I clinical trial of SAHA in lupus patients next year. Phase I studies are primarily concerned with assessing a drug’s safety.

Mishra said it would be a double blind study, in which neither doctor nor patient will know whether they received SAHA or an inert placebo until the end of the study.

The compound is the second that Mishra and his colleagues have tested in mice that may lead to new treatment of systemic lupus. In February 2003 they reported in the Journal of Clinical Investigation that trichostatin A, or TSA, reduced excess protein in urine, inflammation of the kidneys and spleen weight.

Mishra’s colleagues in the study included Christopher M. Reilly, Ph.D., from Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech in Blacksburg, Va., Gary S. Gilkeson M.D., of the Medical University of South Carolina in Charleston, and scientists at the University of Miami Medical Center in Miami and Memorial Sloan-Kettering Cancer Center in New York. Reilly and Gilkerson were involved in the TSA research as well.

Robert Conn | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>