"Other studies have indicated a benefit for heart attack patients in beginning treatment with statins relatively early, so today the standard practice is to prescribe them upon discharge," says R. Scott Wright, M.D., the Mayo Clinic cardiologist who was the studys lead investigator in North America. "Our new findings suggest they should be given even earlier, as soon as the patient arrives at the hospital."
The PRINCESS Trial (The PRevention of Ischemic EveNts by Early Treatment of CErivaStatin Study) was designed to test whether very early initiation of statin therapy in hospitalized heart attack patients would prevent deaths and additional heart attacks and reduce the need for bypass surgery or angioplasty.
Within 48 hours of hospitalization, 3,605 patients at 260 medical centers in Europe, Israel, Canada and the United States were randomly assigned to receive either cerivastatin, a potent statin agent, or a placebo. Neither patients nor their physicians knew whether they were receiving the statin or the sugar pill initially, but all of the patients were switched to the statin after three months. Because statins had been proven beneficial as a later-term treatment, withholding the cholesterol-lowering medication for a prolonged period would have been unethical. In the midst of the study, however, cerivastatins manufacturer withdrew it from the market due to safety concerns, so the researchers were only able to follow the participants for 4.5 months.
Lee Aase | EurekAlert!
Researchers simplify tiny structures' construction drip by drip
12.11.2018 | Princeton University, Engineering School
Mandibular movement monitoring may help improve oral sleep apnea devices
06.11.2018 | Elsevier
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences