Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study suggests immediate statins for heart attack patients

31.08.2004


"Other studies have indicated a benefit for heart attack patients in beginning treatment with statins relatively early, so today the standard practice is to prescribe them upon discharge," says R. Scott Wright, M.D., the Mayo Clinic cardiologist who was the study’s lead investigator in North America. "Our new findings suggest they should be given even earlier, as soon as the patient arrives at the hospital."



The PRINCESS Trial (The PRevention of Ischemic EveNts by Early Treatment of CErivaStatin Study) was designed to test whether very early initiation of statin therapy in hospitalized heart attack patients would prevent deaths and additional heart attacks and reduce the need for bypass surgery or angioplasty.

Within 48 hours of hospitalization, 3,605 patients at 260 medical centers in Europe, Israel, Canada and the United States were randomly assigned to receive either cerivastatin, a potent statin agent, or a placebo. Neither patients nor their physicians knew whether they were receiving the statin or the sugar pill initially, but all of the patients were switched to the statin after three months. Because statins had been proven beneficial as a later-term treatment, withholding the cholesterol-lowering medication for a prolonged period would have been unethical. In the midst of the study, however, cerivastatin’s manufacturer withdrew it from the market due to safety concerns, so the researchers were only able to follow the participants for 4.5 months.


The 1,795 patients initially taking the statin were significantly more likely to reach target levels for LDL (bad) cholesterol, and significantly less likely to have another heart attack or to need surgical or catheter-based interventions to improve blood flow to their hearts during the 4.5 months of follow up.

Dr. Wright says the current study confirms Mayo Clinic’s findings from a retrospective study published in 2001, and indicates that the patient benefits observed are not limited to this particular drug (which is no longer on the market), but are a class effect for statins as a whole. "It is highly unlikely that these results would only apply to cerivastatin, because our previous retrospective study that showed similar benefits involved patients taking a variety of statins," Dr. Wright explains. "By the same token, this broad-based study involving hundreds of hospitals shows that the gains from early statin therapy are not unique to academic medical centers like Mayo Clinic, but can be realized everywhere.

"Physicians should begin treatment of heart attack patients with statins as soon as possible upon admission to the hospital," says Dr. Wright. "And patients should see these results as another reason for them to adhere to the statin therapy prescribed by their physicians."

Lee Aase | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Studies and Analyses:

nachricht Graphene gives a tremendous boost to future terahertz cameras
16.04.2019 | ICFO-The Institute of Photonic Sciences

nachricht Mount Kilimanjaro: Ecosystems in Global Change
28.03.2019 | Julius-Maximilians-Universität Würzburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>