Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Moderate exercise and simple dietary supplements significantly reduce risk of atherosclerosis

25.05.2004


Moderate exercise in conjunction with common dietary supplements significantly reduce the risk of atherosclerosis because, combined, they boost the body’s production of nitric oxide, which protects against a variety of cardio-vascular disorders, a new UCLA study led by 1998 Nobel Laureate in medicine Louis J. Ignarro shows.



The study, "Long Term Beneficial Effects of Physical Training and Metabolic Treatment on Atherosclerosis in Hypercholesterolemic Mice," will be published the week of May 24 in the online edition of the Proceedings of the National Academy of Sciences (www.pnas.org). It found that moderate exercise reduced the development of atherosclerosis, or hardening of the arteries, in mice that are genetically prone to heart disease, because exercise alone has been shown to increase nitric oxide in the body. Adding the amino acid L-arginine and the anti-oxidants Vitamins C and E to the mix, however, significantly magnified the effect, said Ignarro, professor of molecular and medical pharmacology in the David Geffen School of Medicine at UCLA.

And what’s good for mice is good for humans, said Ignarro, who shared the Nobel Prize for his discoveries in the role that nitric oxide (NO) plays in the cardiovascular system.


"It wasn’t just exercise, it was exercise combined with two common dietary supplements," he said. "This is the first study that shows that if you exercise in addition to taking dietary supplements you have a markedly enhanced production of nitric oxide--in science, we like to call it a synergistic effect."

The researchers studied six groups of eight-week-old LDL receptor-deficient male mice with high cholesterol over 18 weeks. The mice were randomly divided into three dietary groups: one fed a high cholesterol diet alone, another fed a high cholesterol diet along with the antioxidant vitamins C and E, and a third fed a high cholesterol diet and given both the antioxidants and L-arginine. Some of the mice were also put on a swimming regimen while others did not exercise.

Researchers found that the mice from all three dietary groups lost weight and had lower cholesterol when they exercised. They also found that atherosclerotic legions were significantly reduced in the mice whose diets included the antioxidants and amino acid.

Here’s how exercise, L-arginine and vitamins C and E work together. Exercise increases the amount endothelial NO synthase, an enzyme that converts L-arginine to nitric oxide, which in turn lowers abnormally elevated blood pressure, prevents unwanted blood clotting and early inflammation associated with coronary artery disease, and protects against stroke and myocardial infarction. The antioxidant vitamins C and E work together to remove destructive oxidants from the blood stream, thereby stabilizing the nitric oxide, which can thus rise to higher levels in the blood stream and produce a more beneficial effect.

Sedentary mice fed with the supplements showed a 40 percent reduction in atherosclerosis lesions compared with the mice that were on a regular, high cholesterol diet but neither given the supplements nor put on an exercise regimen. The mice that exercised, but were not fed the supplements, showed a 35 percent reduction in the legions.

"This is interesting, because it shows that the supplements work well even in the absence of exercise," Ignarro said.

Ignarro recommends making simple lifestyle changes that include moderate exercise, eating a low-fat diet, and taking dietary supplements that are commercially available anywhere, which together can make a difference in one’s vascular health. "I would say just do it," he said. "It works in mice, it’ll work in humans."



Grants from the National Institutes of Health, the Mayo Foundation, and National Research Funds from the University of Naples supported the research.

Other researchers included Sharon Williams-Ignarro of the division of anesthesiology at the UCLA medical school; Claudio Napoli, Filomena de Nigris, Loredana Rossi, Carmen Guarino, Gelsomina Mansueto, Francesco Di Tuoro, Orlando Pignalosa, Gaetano De Rosa and Vicenzo Sica of the University of Naples in Italy; and Lilach O. Lerman of the Mayo Clinic Foundation in Rochester, N.Y.

Enrique Rivero | EurekAlert!
Further information:
http://www.ucla.edu/

More articles from Studies and Analyses:

nachricht Self-organising system enables motile cells to form complex search pattern
07.05.2019 | Westfälische Wilhelms-Universität Münster

nachricht Mouse studies show minimally invasive route can accurately administer drugs to brain
02.05.2019 | Johns Hopkins Medicine

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

Im Focus: Tiny light box opens new doors into the nanoworld

Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.

Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...

Im Focus: Cost-effective and individualized advanced electronic packaging in small batches now available

Fraunhofer IZM is joining the EUROPRACTICE IC Service platform. Together, the partners are making fan-out wafer level packaging (FOWLP) for electronic devices available and affordable even in small batches – and thus of interest to research institutes, universities, and SMEs. Costs can be significantly reduced by up to ten customers implementing individual fan-out wafer level packaging for their ICs or other components on a multi-project wafer. The target group includes any organization that does not produce in large quantities, but requires prototypes.

Research always means trying things out and daring to do new things. Research institutes, universities, and SMEs do not produce in large batches, but rather...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Concert of magnetic moments

14.06.2019 | Information Technology

Materials informatics reveals new class of super-hard alloys

14.06.2019 | Materials Sciences

New imaging modality targets cholesterol in arterial plaque

14.06.2019 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>