Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chronic fatigue syndrome and Gulf War veterans

14.05.2004


Chronic Fatigue Syndrome (CFS) is nearly four times as common in veterans of the first Persian Gulf War as in nonveterans, according to a new study. The study, to be published May 14, 2004 in the online edition of Muscle & Nerve, examined the possibility that genetic factors may play a role in developing the disease. The full study will be available via Wiley InterScience .



Fatigue that has no known medical cause, lasts more than six months, produces a substantial decrease of activity and is accompanied by symptoms associated with infection, as well as rheumatological, and neuropsychiatric symptoms, is known as CFS; idiopathic chronic fatigue (ICF) is fatigue without other symptoms or identifiable cause. CFS/ICF sometimes occurs in an almost epidemic fashion, such as in Gulf War veterans, but its cause is unknown. Genetic factors appear to play a role in both Gulf War veterans and civilian populations. Partial defects in one or more genes combined with environmental factors can result in conditions that include fatigue as a prominent feature. Previous studies have shown that mutations in the myoadenylate deaminase gene (AMPD1) and the carnitine palmitoyltransferase II (CPT2) gene can produce pain, stiffness, cramps or fatigue following strenuous exercise, while a genetic variant known as the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme or ACE (DCP1) gene may impact performance and endurance in trained athletes and army recruits.

In this new study, Drs.Georgirene Vladutiu of the State University of New York at Buffalo and Benjamin Natelson of UMDNJ-New Jersey Medical School evaluated DNA from blood samples collected from 49 Gulf War veterans and 61 nonveterans with CFS/IFS and 30 veterans and 45 nonveterans who were healthy. Blood samples were analyzed for mutations in the AMPD1, DCP1, and CPT2 genes. No significant differences were found in variations of the AMPD1 and CPT2 genes in any of the four groups. However, Gulf War veterans with CFS/ICF showed a higher prevalence of the D variant in the DCP1 gene. Veterans with the DD genotype (which has been associated with alcoholism and cardiac disease) were 8 times more likely to develop CFS or ICF than those with the lower prevalence II genotype.


These results suggest that there may be an interaction between these genetic variants and some factor unique to deployment to the Persian Gulf. If they are supported by future research examining veterans of different wars and war zones, it may be that variants of the ACE gene could be a biological marker for increased risk of war-related illness.

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Self-organising system enables motile cells to form complex search pattern
07.05.2019 | Westfälische Wilhelms-Universität Münster

nachricht Mouse studies show minimally invasive route can accurately administer drugs to brain
02.05.2019 | Johns Hopkins Medicine

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

Im Focus: Tiny light box opens new doors into the nanoworld

Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.

Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...

Im Focus: Cost-effective and individualized advanced electronic packaging in small batches now available

Fraunhofer IZM is joining the EUROPRACTICE IC Service platform. Together, the partners are making fan-out wafer level packaging (FOWLP) for electronic devices available and affordable even in small batches – and thus of interest to research institutes, universities, and SMEs. Costs can be significantly reduced by up to ten customers implementing individual fan-out wafer level packaging for their ICs or other components on a multi-project wafer. The target group includes any organization that does not produce in large quantities, but requires prototypes.

Research always means trying things out and daring to do new things. Research institutes, universities, and SMEs do not produce in large batches, but rather...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Concert of magnetic moments

14.06.2019 | Information Technology

Materials informatics reveals new class of super-hard alloys

14.06.2019 | Materials Sciences

New imaging modality targets cholesterol in arterial plaque

14.06.2019 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>