Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new Twist on bone development

16.03.2004


A new research study reveals that formation of the cells that build bone tissue, called osteoblasts, is suppressed by a complicated inhibitory signal and that formation of the skeleton proceeds only after relief of the inhibition. This inhibitory signal is part of normal development, and without it, bone formation proceeds prematurely and abnormally.



A gene called Runx2 is the earliest and most specific indicator of osteoblast formation. However, Runx2 expression precedes the actual appearance of osteoblasts by about 4 days. Dr. Gerard Karsenty from Baylor College of Medicine in Houston, Texas, and colleagues were interested in determining what other regulatory molecules may be involved in this process during the delay period. They focused on proteins called Twist-1 and Twist-2 that are present in decreased amounts in people with Saethre-Chotzen syndrome, a disease characterized by overproduction of bone tissue. The researchers discovered that Twist proteins are found in Runx2-containing cells very early in development and that osteoblast development occurs only after Twist amounts decrease. Further, without Twist proteins, osteoblasts form too early and too much Twist inhibits osteoblast formation but does not influence that amount of Runx2 expression.

The researchers conclude that Twist proteins transiently inhibit osteoblast differentiation during formation of the skeleton by negatively regulating Runx2. According to Dr. Karsenty, "These results reveal an unanticipated complexity in osteoblast differentiation whose initiation is determined by the relief of an inhibition." The researchers went on to identify a novel region of the Twist proteins, named the Twist box, and characterized this region as the specific site required for interaction between the two Twist proteins and Runx2. The authors point out that some Saethre-Chotzen patients have a mutation that results in a loss of the Twist box and that this mutation could easily explain the occurrence of the disease.



P. Bialek, B. Kern, X. Yang, M. Schrock, D. Sosic, N. Hong, H. Wu, K. Yu, D.M. Ornitz, E.N. Olson, M.J. Justice, and G. Karsenty: "A Twist Code Determines the Onset of Osteoblast Differentiation"

Published in Developmental Cell, Volume 6, Number 3, March 2004, pages 423-436.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Staying in Shape

16.08.2018 | Life Sciences

Diving robots find Antarctic seas exhale surprising amounts of carbon dioxide in winter

16.08.2018 | Earth Sciences

Protein droplets keep neurons at the ready and immune system in balance

16.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>