Scientists have identified a gene in the cerebral cortex that apparently controls the developmental clock of embryonic nerve cells, a finding that could open another door to tissue replacement therapy in the central nervous system. In a new study, the researchers found that they could rewind the clock in young cortical cells in mice by eliminating a gene called Foxg1. The finding could potentially form the basis of a new method to push progenitor cells in the brain to generate a far wider array of tissue than is now possible.
The study, led by researchers at NYU School of Medicine, is published in the January 2, 2004 issue of Science magazine.
"What we found was a complete surprise," says Gordon Fishell, Ph.D., Associate Professor in the Department of Cell Biology at New York University School of Medicine. "No one had believed that it was possible to push back the birth date of a cortical neuron. There is this central tenet governing the process of brain development, which says that late progenitor cells [forerunners of mature cell types] cannot give rise to cell types produced earlier in development," he explains.
Pamela McDonnell | EurekAlert!
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