Nasopharyngeal carcinoma (NPC) is cancer of the nasopharynx (the uppermost part of the throat that connects the back of the nose to the back of the throat). Published studies suggested genetic predisposition as well as infections by a member of the herpesvirus in the development of NPC. Investigation of both aspects is currently conducted in Universiti Malaysia Sarawak.
Globally, NPC has its highest incidence in South East Asia, and is more prevalent in the Chinese population. Comparison between mainland Chinese and Caucasian showed a 40-fold risk of NPC occurrence in the former.
In Malaysia, the Chinese population represents the highest risk group, constituting 72% of the reported cases. Like most types of cancer, however, the origin of NPC is most probably multifactorial and is specified by several genes. Indeed, other research findings had implicated several genes in NPC tumour progression.
To this date, there are no published studies to correlate the functions, activities and interactions among these genes with regards to the development of NPC. The hypothesis therefore is that there are significant relationships and interactions among these known susceptibility genes (and others?) and their physiological targets in the predisposition and development of NPC.
As the occurrence of NPC is ethnically biased, the genetic background of the susceptible race group probably plays an important role in their predisposition. The question is, what are the genetic markers responsible for these high-risk groups and what are the underlying mechanism(s) of these genetic markers in the predisposition and development of NPC.
On the other hand, Epstein-Barr Virus (EBV) association with NPC has been reported extensively. The tight association indicates a role for EBV in the development of NPC but the mechanism remains unknown, though chromosome rearrangements (specific genetic sequence rearrangements) have been widely detected in NPC cases. While EBV infection and chromosomal rearrangements are commonly observed in NPC, there is no published study looking into their relationship in terms of NPC development.
To unravel the mechanism leading to NPC, a research group in UNIMAS has narrowed their target on the activity of some genes and discovered the involvement of genes that had not been implicated before. The group is also looking at the role of EBV-induced apoptosis in chromosome rearrangements in NPC and their current findings have put support to their hypothesis, qualifying further investigation into other regions of chromosome rearrangements.
It is hoped that the combine outcomes of both studies will give more insight and information to the field of NPC research.
Resni Mona | ResearchSEA
Drought hits rivers first and more strongly than agriculture
06.09.2018 | Max-Planck-Institut für Biogeochemie
Landslides triggered by human activity on the rise
23.08.2018 | European Geosciences Union
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
17.10.2018 | Event News
16.10.2018 | Event News
02.10.2018 | Event News
18.10.2018 | Life Sciences
18.10.2018 | Earth Sciences
18.10.2018 | Life Sciences