Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research findings enable more reliable prognoses for breast cancer

15.05.2008
Researchers at Umeå University in Sweden have shown that the length of telomeres in blood cells in newly diagnosed breast cancer patients is tied to survival rates. The study, published in the journal Cancer Research, was carried out by a research team headed by Professor Göran Roos at the Department of Medical Bioscience, Pathology.

The study shows that the telomere length in blood cells is associated with prognosis for breast cancer. The blood cells of the cancer patients in the study had somewhat longer telomeres than those of controls. It is interesting to note that within the tumor group patients with longer telomeres (= longer than the mean length of telomeres) had a significantly poorer prognosis than did patients with shorter telomeres. This difference in survival was above all seen in patients with more advanced disease, that is, with larger tumors and metastases in local lymph glands.

It is particularly important that the telomere length in these blood cells proved to be a prognostic marker that is independent of other well-known prognostic markers (tumor size, tumor metastasis). In other words, this new biological marker appears to be able to tell us more about the future prospects of cancer patients than previously known markers can.

The tips of chromosomes, telomeres, are important for the genetic stability of our cells. In normal cells, telomeres are shortened each time cells divide, whereas cancer cells usually have stable telomere length. This stability helps provide cancer cells with eternal life. The length of a cell's telomeres is determined by the balance of positive and negative factors, many of which are unknown.

Just why breast cancer patients with longer telomeres in normal blood cells have poorer prognoses than other patients is unclear at present. A number of explanations are under discussion. One probable hypothesis is that patients' telomere lengths are a reflection of presently unknown functions of the immune defense system. Preliminary unpublished data from the research team show that this biological marker can provide prognostic information for other tumor diseases as well. This makes it even more important to understand the mechanisms behind the observed differences in telomere length.

The study was performed in collaboration with colleagues at the oncology and medical clinics at Norrland University Hospital and Malmö Academic Hospital. The study comprises 265 patients who gave blood samples directly after they were diagnoses with breast cancer and 446 controls.

For more information, please contact Professor Göran Roos, Department of Medical Bioscience, Pathology, phone: +46 (0)90-785 18 01; cell phone: +46 (0)70-630 86 92; or e-mail goran.roos@medbio.umu.se.

Pressofficer Bertil Born; +46-090 786 60 58;bertil.born@adm.umu.se;

Reference:
Svenson U, Nordfjäll K, Stegmayr B, Manjer J, Nilsson P, Tavelin B, Henriksson R, Lenner P, Roos G. Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Research 2008, published May 15.

Bertil Born | idw
Further information:
http://cancerres.aacrjournals.org/future/68.10.shtml
http://www.vr.se

More articles from Studies and Analyses:

nachricht New model connects respiratory droplet physics with spread of Covid-19
21.07.2020 | University of California - San Diego

nachricht Risk of infection with COVID-19 from singing: First results of aerosol study with the Bavarian Radio Chorus
03.07.2020 | Klinikum der Universität München

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AI & single-cell genomics

New software predicts cell fate

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

Im Focus: NYUAD astrophysicist investigates the possibility of life below the surface of Mars

  • A rover expected to explore below the surface of Mars in 2022 has the potential to provide more insights
  • The findings published in Scientific Reports, Springer Nature suggests the presence of traces of water on Mars, raising the question of the possibility of a life-supporting environment

Although no life has been detected on the Martian surface, a new study from astrophysicist and research scientist at the Center for Space Science at NYU Abu...

Im Focus: Manipulating non-magnetic atoms in a chromium halide enables tuning of magnetic properties

New approach creates synthetic layered magnets with unprecedented level of control over their magnetic properties

The magnetic properties of a chromium halide can be tuned by manipulating the non-magnetic atoms in the material, a team, led by Boston College researchers,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

First radio detection of an extrasolar planetary system around a main-sequence star

04.08.2020 | Physics and Astronomy

The art of making tiny holes

04.08.2020 | Physics and Astronomy

Early Mars was covered in ice sheets, not flowing rivers

04.08.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>