Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study breaks ground in revealing how neurons generate movement

28.04.2008
When the eye tracks a bird’s flight across the sky, the visual experience is normally smooth, without interruption. But underlying this behavior is a complex coordination of neurons that has remained mysterious to scientists.

Now, UCSF researchers have broken ground in understanding how the brain generates this tracking motion, a finding that offers a window, they say, into how neurons orchestrate all of the body’s movements.

The study, reported in the April 24 issue of Neuron, reveals that individual neurons do not fire independently across the entire duration of a motor function as traditionally thought. Rather, they coordinate their activity with other neurons, each firing at a particular moment in time.

“Scientists have known that neurons that connect to muscles initiate movement in a coordinated fashion. But they have not known how the neurons we are studying – which coordinate these front-line neurons -- commit the brain to move the eyes,”says co-lead author David Schoppik, PhD, who conducted the study while a doctoral candidate in the laboratory of senior author Stephen Lisberger, PhD, at the University of California, San Francisco.

“For decades, scientists have been asking, ‘Do the signals involve a handful of neurons or thousands? What is the nature of the commands?’ The classical understanding has been that one class of neuron is responsible for one movement, such as generating eye movement to the left, and that it remains active across the entire duration of a behavior,” he says.

“The new findings suggest a totally different way of looking at how movement is controlled across time,” says Lisberger, a Howard Hughes Medical Institute Investigator at UCSF, where he is professor of physiology, director of the W.M. Keck Foundation Center for Integrative Neuroscience, and co-director of the Sloan Center for Theoretical Neurobiology.

The findings, the researchers say, could inform efforts to develop neural prosthetics to treat paralysis and motor dysfunctions, such as those resulting from stroke. “The brain’s messages don’t reach the muscles in these conditions,” says Schoppik, “so it’s critical that the drive to these prosthetics reflect what the brain is trying to do to move muscles. Understanding how multiple neurons work together could influence the type of software created to drive these devices.”

The investigation of how neurons give rise to motor behaviorshas been stymied until now, says Schoppik, by the difficulties inherent in studying more than one neuron in action at a time during the course of a behavior. In the current study, the scientists overcame this obstacle in a study of macaque monkeys that had been trained to track a moving object with their eyes.

Basing their approach on two key pieces of information -- first, that when a neuron responds to a stimulus there is always a slight variation in its performance, a phenomenon that neuroscientists traditionally refer to as “noise,” and, second, that each attempt of the eye to pursue a moving target is also unique – they proposed that some aspects of neural variation may reflect behavioral variation.

They used this inherent variability as a probe. Using a formula from financial securities market analysis that looks at how individual stocks behave at a given time within the context of fluctuations in the larger financial market, they explored how individual neurons would behave relative to their neighbors.

They compared the deviations from the average spiking activity of single neurons and simultaneous deviations from the mean eye velocity. They also measured the degree to which variation shared across two pairs of concurrently active neurons.

The data demonstrated that individual neurons encode different aspects of behavior, controlling eye velocity fluctuations at particular moments during the course of eye movement, while the population of neurons collectively tiles the entire duration of the movement.

The analysis also revealed the strength of correlations in the eye movement predictions derived from pairs of simultaneously recorded neurons, and suggests, the researcher say, either that a small number of neurons are sufficient to drive the behavior at any given time or that many neurons operate collectively at each moment.

The finding, says Lisberger, underscores the importance of recording for more than one neuron at a time. “There is a lot that we can learn from how multiple neurons interact.”

The other co-author of the study was Katherine Nagel, PhD, at the time a doctoral candidate in the laboratory of Allison J. Doupe, MD, PhD, a professor of psychiatry and physiology and a member of the Keck Center for Integrative Neuroscience at UCSF.

The study was funded by the Howard Hughes Medical Institute and by a Conte Center for Neuroscience Research grant.

UCSF is a leading university dedicated to defining health worldwide through advanced biomedical research, graduate level education in the life sciences and health professions, and excellence in patient care.

Jennifer O’Brien | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Studies and Analyses:

nachricht Researchers simplify tiny structures' construction drip by drip
12.11.2018 | Princeton University, Engineering School

nachricht Mandibular movement monitoring may help improve oral sleep apnea devices
06.11.2018 | Elsevier

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

Im Focus: Nanorobots propel through the eye

Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.

Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

In focus: Peptides, the “little brothers and sisters” of proteins

12.11.2018 | Life Sciences

Materials scientist creates fabric alternative to batteries for wearable devices

12.11.2018 | Materials Sciences

A two-atom quantum duet

12.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>