Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Major discovery in the treatment of aortic valve stenosis

22.04.2008
Experimental study on most common form of heart valve disease in Western countries may lead to new treatments

A team of scientists from the Université de Montréal and the Montreal Heart Institute Research Centre, led by Dr. Jean-Claude Tardif, has completed an important study that show how a new type of medication can lead to an improvement in the aortic valve narrowing.

This type of treatment based on raising high-density lipoproteins (HDL), the so-called good cholesterol level in patients suffering from aortic valve stenosis, could potentially transform the treatment approach of this disease, notably by avoiding open heart surgery. Study results have been published on-line in the British Journal of Pharmacology.

Renewed hope for patients

“We are delighted to see that the new type of drug used, based on HDL, led to the regression of the aortic valve stenosis in an experimental model,” underlined Dr. Jean-Claude Tardif, director of the Montreal Heart Institute Research Centre and professor of medicine at the Montreal Heart Institute and the Université de Montréal.

“This important discovery warrants further clinical studies on patients suffering from this frequent disease. This new medical option could possibly provide us with an alternative to the cardiac surgery of aortic valve replacement.”

What is aortic valve stenosis?

Aortic valve stenosis is the most common form of heart valve disease in Western countries. In Canada, it could affect some 150,000 persons. The disease is characterized by a narrowing of the aortic valve opening, causing a difference in blood pressure between the heart and the rest of the body, which is particularly dangerous for the patient.

The main symptoms of severe aortic valve stenosis are exercise intolerance, angina and syncope (fainting). Its frequency in the population aged over 65 is two percent to four percent. Its major complications are, in addition to the need for cardiac surgery, heart failure and sudden death. The disease therefore represents a major health problem with dramatic consequences if replacement surgery is not performed in time. In the United States, about 50,000 patients a year must undergo aortic valve replacement surgery.

Details on the study

The study was conducted on animals fed a diet rich in cholesterol until aortic valve stenosis was detected by echocardiography, the medical imaging ultrasound system used for humans. The animals were then divided into two groups: a control group given injections of a neutral solution, and a group treated for two weeks with injections of a drug based on raising the “good cholesterol” (ApoA-I mimetic peptide).

The findings were particularly interesting, since after only 14 days of treatment, the aortic valve opening in subjects had returned again to almost normal in the treated group, whereas it had improved by a mere 13 percent by eliminating the high-fat diet in the control group.

What’s more, the thickness of the aortic valve decreased by 21 percent in the treated group, while remaining unchanged in the control group.Microscopic analysis revealed that valve lesions were significantly less extensive in the treatment group than in the control group. The treatment also reduced aortic valve calcifications.

Doris Prince | EurekAlert!
Further information:
http://www.icm-mhi.org
http://www.umontreal.ca/english/index.htm

More articles from Studies and Analyses:

nachricht Graphene gives a tremendous boost to future terahertz cameras
16.04.2019 | ICFO-The Institute of Photonic Sciences

nachricht Mount Kilimanjaro: Ecosystems in Global Change
28.03.2019 | Julius-Maximilians-Universität Würzburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unprecedented insight into two-dimensional magnets using diamond quantum sensors

For the first time, physicists at the University of Basel have succeeded in measuring the magnetic properties of atomically thin van der Waals materials on the nanoscale. They used diamond quantum sensors to determine the strength of the magnetization of individual atomic layers of the material chromium triiodide. In addition, they found a long-sought explanation for the unusual magnetic properties of the material. The journal Science has published the findings.

The use of atomically thin, two-dimensional van der Waals materials promises innovations in numerous fields in science and technology. Scientists around the...

Im Focus: Full speed ahead for SmartEEs at Automotive Interiors Expo 2019

Flexible, organic and printed electronics conquer everyday life. The forecasts for growth promise increasing markets and opportunities for the industry. In Europe, top institutions and companies are engaged in research and further development of these technologies for tomorrow's markets and applications. However, access by SMEs is difficult. The European project SmartEEs - Smart Emerging Electronics Servicing works on the establishment of a European innovation network, which supports both the access to competences as well as the support of the enterprises with the assumption of innovations and the progress up to the commercialization.

It surrounds us and almost unconsciously accompanies us through everyday life - printed electronics. It starts with smart labels or RFID tags in clothing, we...

Im Focus: Energy-saving new LED phosphor

The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.

Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.

Im Focus: Quantum gas turns supersolid

Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.

Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...
All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

Researchers discover surprising quantum effect in hard disk drive material

26.04.2019 | Physics and Astronomy

Hopkins researchers ID neurotransmitter that helps cancers progress

26.04.2019 | Life Sciences

Unprecedented insight into two-dimensional magnets using diamond quantum sensors

26.04.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>