Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Inhibiting Stress Oxidant May be New Therapy for COPD

21.04.2008
A study in Clinical and Experimental Pharmacology and Physiology published by Wiley-Blackwell has showed that the generation of oxidative stress increases pulmonary inflammation – thus encouraging the development of airway obstruction associated with chronic obstructive pulmonary disease (COPD).

The study “Oxidative Stress is an Important Component of Airway Inflammation in Mice Exposed to Cigarette Smoke or Lipopolysaccharide” investigates the inflammatory responses in oxidative stress-deficient mice exposed to cigarette smoke. The authors employ a cigarette smoke model to understand the role of oxidative stress in the pathogenesis of COPD, and suggested that further investigations of the efficacy of new compounds that may help treat respiratory disorders.

Cigarette smoking is the main cause of respiratory disorders such as chronic bronchitis, emphysema and COPD. Smokers and patients with COPD generally display an increased oxidative stress level as compared to healthy patients.

Lead author Vincent Lagente, Professor of Pharmacology at the University of Rennes 1 in France says, “Overwhelming evidence shows that- compared to non-smokers and healthy patients – smokers and patients with COPD display an increased level of oxidative stress, and suffer from an imbalance in oxidants in airway inflammation. As classic anti-inflammatory compounds are ineffective in treating respiratory disorders, and the effects of cigarette smoke on COPD are still not completely understood, we have developed a cigarette exposure protocol that results in airway inflammation to better understand the physiopathology of the inflammatory process.”

In examining the response of mice exposed to cigarette smoke, researchers found that those with reduced oxidative stress showed lesser inflammatory symptoms – hence suggesting the association of oxidative stress with COPD and supporting the development of anti-oxidant therapy for smoking related-diseases.

This paper is published in the May/June 2008 issue of Clinical and Experimental Pharmacology and Physiology(Vol. 35, Issue 5-6, pg. 601-605).
The article abstract is available free online at: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1440-1681.2007.04848.x

Media wishing to receive a PDF or schedule media interviews with the authors should contact Alina Boey, PR & Communications Manager Asia at aboey@wiley.com.sg or phone 65-96565580.

About Wiley-Blackwell
Wiley-Blackwell was formed in February 2007 as a result of the acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc., and its merger with Wiley’s Scientific, Technical, and Medical business. Together, the companies have created a global publishing business with deep strength in every major academic and professional field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-reviewed journals and an extensive collection of books with global appeal. For more information on Wiley-Blackwell, please visit www.blackwellpublishing.com or http://interscience.wiley.com.
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for 200 years, helping people around the world meet their needs and fulfill their aspirations. Since 1901, Wiley and its acquired companies have published the works of more than 350 Nobel laureates in all categories: Literature, Economics, Physiology/Medicine, Chemistry and Peace.

Our core businesses include scientific, technical, medical and scholarly journals, encyclopedias, books, and online products and services; professional/trade publishes books, subscription products, training materials, and online applications and websites; and educational materials for undergraduate and graduate students and lifelong learners. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company’s Web site can be accessed at http://www.wiley.com. The Company is listed on the New York Stock Exchange under the symbols JWa and JWb.

Alina Boey | alfa
Further information:
http://www.blackwellpublishing.com/press/pressitem.asp?ref=1691

More articles from Studies and Analyses:

nachricht Researchers simplify tiny structures' construction drip by drip
12.11.2018 | Princeton University, Engineering School

nachricht Mandibular movement monitoring may help improve oral sleep apnea devices
06.11.2018 | Elsevier

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

Im Focus: Nanorobots propel through the eye

Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.

Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

In focus: Peptides, the “little brothers and sisters” of proteins

12.11.2018 | Life Sciences

Materials scientist creates fabric alternative to batteries for wearable devices

12.11.2018 | Materials Sciences

A two-atom quantum duet

12.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>