Even small increases in serum creatinine levels during hospitalization raise the risk of end stage renal disease and mortality of elderly patients over the long term, according to a University of Alabama at Birmingham (UAB) study in the March issue of the Archives of Internal Medicine.
The 10-year retrospective study, led by UAB nephrologist Britt Newsome, M.D, is the first systematic description of creatinine increase and longer-term end stage renal disease and mortality risk. Previous studies showed a relationship between reductions in kidney function during hospitalization and higher mortality rates.
"Previous studies have shown that a rise in serum creatinine level of 0.3 milligrams per deciliter or more during hospitalization is associated with higher in-hospital mortality, longer stays and higher costs," Newsome said. "However, little was known about the long-term risks of subsequent end-stage renal disease and mortality in this population. The long-term risks we observed suggest that even the least severe category of kidney injury may indicate a worse prognosis."
The study looked at 87,094 Medicare beneficiaries admitted to 4,473 hospitals across the country suffering from a heart attack, or acute myocardial infarction. They studied changes in creatinine levels of those patients from 0.1 to 3.0 milligrams per deciliter. The mean age of the patients was 77.1 years old.
Incidences of end stage renal disease and death were greatest among patients with larger changes in creatinine level, and all levels of serum creatinine increase were associated with a greater risk of end stage renal disease and death.
"We chose to examine a population of Medicare beneficiaries because the incidence of acute kidney injury has been increasing in this population for the past 10 years," Newsome said. "Further, patients with cardiovascular disease are at a particularly high risk of chronic kidney disease as well as acute kidney injury. In future studies we will want to determine if this relationship exists in patients admitted to the hospital for other conditions."
With these findings, the study calls for clinicians to closely monitor and aggressively treat patients experiencing increases in creatinine levels.
"The study also shows that giving patients beta blockers and aspirin can help treat these patients and possibly prevent death in the long term, regardless of creatinine change during hospitalization," Newsome said
Other UAB authors on the paper were Jeroan J. Allison, M.D.; David Warnock, M.D.; and Catarina I. Kiefe, M.D., Ph.D.
Additional authors are William M. McClellan, M.D., Emory University School of Medicine; Charles A. Herzog, M.D., Cardiovascular Special Studies Center, U.S. Renal Data System, Minneapolis, Minn.; and Paul W. Eggers, Ph.D., the National Institute of Diabetes and Digestive and Kidney Diseases.Media Contact
Jennifer Lollar | EurekAlert!
ECG procedure indicates whether an implantable defibrillator will extend a patient's life
02.09.2019 | Technische Universität München
Fracking prompts global spike in atmospheric methane
14.08.2019 | European Geosciences Union
A very special kind of light is emitted by tungsten diselenide layers. The reason for this has been unclear. Now an explanation has been found at TU Wien (Vienna)
It is an exotic phenomenon that nobody was able to explain for years: when energy is supplied to a thin layer of the material tungsten diselenide, it begins to...
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols.
The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between radiation and matter. Light strikes particles...
Particles that are mere nanometers in size are at the forefront of scientific research today. They come in many different shapes: rods, spheres, cubes, vesicles, S-shaped worms and even donut-like rings. What makes them worthy of scientific study is that, being so tiny, they exhibit quantum mechanical properties not possible with larger objects.
Researchers at the Center for Nanoscale Materials (CNM), a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE's Argonne National...
A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.
The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...
Superconductivity has fascinated scientists for many years since it offers the potential to revolutionize current technologies. Materials only become superconductors - meaning that electrons can travel in them with no resistance - at very low temperatures. These days, this unique zero resistance superconductivity is commonly found in a number of technologies, such as magnetic resonance imaging (MRI).
Future technologies, however, will harness the total synchrony of electronic behavior in superconductors - a property called the phase. There is currently a...
02.10.2019 | Event News
02.10.2019 | Event News
19.09.2019 | Event News
21.10.2019 | Materials Sciences
21.10.2019 | Materials Sciences
21.10.2019 | Medical Engineering