Whilst mefloquine has traditionally been considered an effective prevention for long-term malaria chemoprophylaxis, research reported in the open access publication, Malaria Journal, suggests that US military physicians should ensure careful screening processes prior to prescribing and dispensing the drug. Ignoring such contraindications may lead to an increased incidence of psychiatric and neurological disorders.
An epidemiological study from the US Army Center for Health Promotion and Preventive Medicine, led by Remington Nevin, used military medical surveillance and pharmacosurveillance databases to identify contraindications to mefloquine use among a cohort of 11,725 active duty U.S. military personnel, recently deployed to Afghanistan.
The study indicates that 9.6 percent of service members deployed to Afghanistan in early 2007 had evidence of psychiatric, medical or pharmacological contraindications to mefloquine, the primary drug used to protect service members from malaria, which is endemic there. It was also reported that females were twice as likely as males to have a contraindication.
This work underscores the importance of proper systematic screening prior to prescribing and dispensing mefloquine, and the need to provide alternatives to mefloquine suitable for long-term administration among deployed U.S. military personnel.
“Mefloquine is generally considered safe when prescribed and dispensed appropriately, and when used as directed. However, this study provides evidence that mefloquine is not a suitable option for a significant number of deploying U.S. servicemembers.
This study points to the need for enhanced vigilance during pre-deployment medical screening to ensure the appropriate use of this medication, particularly among females, and underscores the need for continued investment in research and development of alternatives to mefloquine that retain the advantages in compliance of a weekly medication.”
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
21.08.2018 | Power and Electrical Engineering
21.08.2018 | Life Sciences
21.08.2018 | Medical Engineering