In both groups 0.4 % of singletons were stillborn, with a definition of stillbirth as a dead child after 22 weeks of gestation. After having been matched with the control group regarding mother's parity and year of birth, the overall risk of stillbirth was found to be marginally higher (1.1 fold) in ART children after adjusting for factors such as maternal age and the child's sex.
"Although the difference in risk of stillbirth is significant between the two groups and the risk is marginally higher with an overrepresentation of 8 per 1,000 pregnancies for singleton ART pregnancies, the overall risk of stillbirth is still low," said Anna-Karina Aaris Henningsen, leading author of the study from Righospitalet University Hospital of Copenhagen. "This means that the individual woman need not be concerned about the risk of stillbirth during pregnancy."
When analysing the stillbirth risk before and after term, no difference was found after 40 weeks of gestation between ART children and their naturally conceived peers. This was also the case when comparing the two cohorts after 37 weeks of gestation. However, until gestational week 40, the group found a 1.2 fold higher risk of stillbirth for ART singletons.
"We believe the difference in risk of stillbirth between ART and NC children seems to occur before 37 weeks of gestation," said Dr. Aaris Henningsen. "It is likely, that some of the difference in risk of stillbirth is related to parental factors in the subfertile mother or father."
When the researchers assessed the risk of total perinatal death (risk of stillbirth and risk of perinatal death until one year of age), children born after ART showed a 1.4 fold increased risk compared to naturally conceived babies. This remained 1.2 fold higher after adjusting for confounding factors and can probably be partly explained by the higher risk of preterm birth among ART children.
"Very few European, non-Nordic, studies exist on stillbirth rates and are mostly based on small numbers," explained Dr. Aaris Henningsen. "Our results come from the largest database on ART children worldwide. The MART group is currently looking at multiple neonatal outcomes including the risk of perinatal death in both singletons and twins and is hoping to have additional data in the near future."
In 2006, the European IVF Monitoring Group (EIM), a working group of ESHRE decided to assess the possibility of using the Nordic ART registers to pool outcome data for infant and maternal health after ART. The Committee on Nordic ART and Safety (CoNARTaS) was established in order to provide a continuous and large scale Nordic monitoring system that reports on safety and quality aspects of ART. The Nordic ART database contains data on all ART pregnancies, deliveries and children born after IVF, Intracytoplasmic Sperm Injection (ICSI) and frozen embryo transfer (FET) in Denmark, Finland, Norway and Sweden.
Abstract no: O-300 Wednesday 6 July 2011, 14.30 hrs CEST (Room K1+K2)
Note: When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.
The figures in the release have been updated since the abstract was submitted to the conference.For further information on the details contained in this press release, contact:
Hanna Hanssen | EurekAlert!
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy