Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Neuroscientists Develop New Computational Model to Analyze Mouse Behavior

04.10.2010
For decades, carefully logging data about how mice go through the motions of their daily routines has been a tedious staple of behavioral and neuroscience research:
• Hour 2, minute 27: mouse 4 is sleeping;
• Hour 3, minute 12: mouse 7 is eating;
and so on. It’s a task most people would happily cede to automation. Now, according to a new study by MIT neuroscientists, that’s finally possible.

In a paper published online Sept. 7, 2010, in the journal Nature Communications, Thomas Serre and a team of colleagues at the McGovern Institute for Brain Research at MIT and the California Institute of Technology describe a new computer system that is as accurate as people in identifying mouse behaviors in videos.

What’s more, the team is making the fully customizable open-source software available for free. Given standard camcorder footage of a mouse, the software will automatically identify a mouse’s behavior frame by frame.

“We measured the agreement between any two human observers and it was more than 70 percent,” said Serre, who joined the faculty of Brown University in January 2010 after conducting his doctoral and postdoctoral studies, including the work described in the paper, in Tomaso Poggio’s lab at MIT. “The system agreed with humans at the same level. There was no significant difference between the annotations provided by our system and any two human observers.”

The value of the software is not only that it could relieve graduate students and lab technicians from some boredom. It takes about 25 person-hours to fully annotate an hour of mouse movies. In a small experiment with 10 mice who are each observed for 5 hours, that’s 1,250 person-hours of work. Because it is computerized, the system might also provide less subjective annotations than a human team would and could therefore be less susceptible to bias.

“This is a small step towards developing automatic tools for quantifying phenotyping of behavior,” said Poggio. “In the quest to understand the causes of mental diseases, labs at McGovern and elsewhere can rely on precise, quantitative and affordable tools to analyze the genes that contribute to disease. The bottleneck is the lack of corresponding techniques for quantifying the behavioral effects of mental diseases in animal models and in humans. The combination of large-scale genotyping and phenotyping will allow powerful data analysis techniques to help uncover the complex relationship between multiple genes and complex behaviors.”

There are a few commercial programs on the market, some of which cost thousands of dollars. They mostly base their behavioral coding on sensors, rather than video, and therefore have agreement rates with human observers of around 60 percent, substantially lower than the rates between people or between people and the system reported in the paper.

Although feats of artificial perception that compare to real perception are notable, it should not be a surprise that the system matches human levels of observation. It is, after all, based on a computer model of how the human brain interprets what it sees.

“It’s mimicking what the visual system does when you process motion,” Serre says.

In addition, the system learns from experience. To train it to detect grooming behavior, for example, the researchers fed the system lots of videos of mice grooming themselves and certified what the behavior was so the system would know. From there the software was able to identify new scenes of grooming without any coaching. In the paper, the team shows that the software is capable of performing the chore even in different strains of mice in a variety of lighting and other conditions. Serre says the software is likely to be easy to train to work with other lab animals.

“Neuroscience is beginning to give us useful blueprints for a more powerful artificial vision technology,” Poggio explains. “It is encouraging that studies of the brain can lead to a system like ours that can help the scientific community better understand mental diseases.”

The paper’s other authors are Hueihan Jhuang, Estibaliz Garrote, Jim Mutch and Tomaso Poggio at MIT, and Xinlin Yu, Vinita Khilnani, and Andrew D. Steele at Caltech.

Funding: McGovern Institute Neurotechnology (MINT) Program at the McGovern Institute for Brain Research at MIT, Broad Fellows Program in Brain Circuitry at Caltech, and the Taiwan National Science Council.

Julie Pryor | Newswise Science News
Further information:
http://web.mit.edu/newsoffice/

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>