Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Metabolic syndrome in living kidney donors worsens function of remaining kidney

21.06.2010
People who donate one of their kidneys experience faster deterioration of their other kidney if they have the metabolic syndrome at the time of donation, a new study finds. The results will be presented Sunday at The Endocrine Society's 92nd Annual Meeting in San Diego.

Each year more than 6,000 adults in the United States are living kidney donors. Over time, these donors typically have some decline in function of their remaining kidney, depending on their age and other factors. However, the new study found that kidney function decreases more than twice as fast in donors who have a cluster of cardiovascular risk factors known as the metabolic syndrome.

"The metabolic syndrome before kidney donation can negatively affect a donor's kidney function outcome," said the study's lead author, Daniel Cuevas-Ramos, MD, a clinical researcher at Mexico's Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. "We recommend that living kidney donors correct any metabolic abnormalities before donation."

Diagnosis of the metabolic syndrome depends on the presence of at least three of the following: a large waistline, low HDL ("good") cholesterol, high triglycerides (levels of fat in the blood), high blood pressure and high blood glucose (blood sugar) at a level considered prediabetes or above. The metabolic syndrome, which affects one in five people in the United States, increases the chance of developing Type 2 diabetes, heart disease and stroke.

Cuevas-Ramos and his colleagues studied 140 adults who donated a kidney. Of those, 28 donors had the metabolic syndrome before donation and 112 did not. Using long-term follow-up data, the investigators determined each donor's kidney function after donation, measured by the glomerular filtration rate, or GFR, on a blood test. In general, a GFR below 70 milliliters per minute indicates below-normal kidney function.

The average time it took for donors' GFR to drop below 70 was less than six years in those who had the metabolic syndrome before donation versus approximately 13 years in donors without the syndrome.

"This study does not suggest that the metabolic syndrome is a contraindication for kidney donation but rather another potential risk factor for decline in renal function," Cuevas-Ramos said.

Medical reasons for rejecting a kidney donor, called contraindications, vary among U.S. transplant centers. However, diabetes, obesity, and high blood pressure are usually contraindications to donating a kidney.

Aaron Lohr | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>