Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Math Boosts Brain Research

11.08.2015

Human memory is the result of different mental processes, such as learning, remembering and forgetting. However, these distinct processes cannot be observed directly. Researchers at the University of Basel now succeeded at describing them using computational models. The scientists were thus for the first time able to identify gene sets responsible for steering specific memory processes. Their results have been published in the current issue of the journal PNAS.

Thanks to our memory we are able to learn foreign languages, solve exams and remember beautiful moments from the past. To ensure optimal memory performance, several distinct cognitive processes have to cooperate. Information is first learned and then stored. Later, when we want to remember them, we depend on a properly functioning retrieval process.


Researchers at the University of Basel succeeded at describing distinct memory processes, such as learning, remembering and forgetting using a computational model.

(Fig: MCN University of Basel)

If all these various memory processes are controlled by the same or by different genes and molecular mechanisms has so far been mostly unknown. One reason for this, is the fact that many of these processes are not amenable to direct measurement and have therefore remained inaccessible for science.

The mathematician Dr. Gediminas Luksys from the transfaculty research platform at the Psychiatric University Clinics Basel and the Faculty of Psychology at the University of Basel has now been able to successfully describe the various human memory processes for the first time. The study used data of over 1700 adults. Thanks to the computational model, the researchers were able to measure the processes and to conduct distinct genetic analyses for the specific mental processes.

Individual processes are based on different gene sets

The results show that distinct genetic profiles underlie specific memory processes: The study reports, for example, associations between a transporter protein set and the process of learning as well as between a cell adhesion set and the process of memory storage. The findings contribute to a better understanding of the complex processes of human memory and could lead to the development of new treatment therapies for various memory disorders in the future.

The current study is part of the Basel Genetics Memory Project led by Prof. Dominique de Quervain and Prof. Andreas Papassotiropoulos. The two co-heads of the transfaculty research platform are dedicated to getting these fundamental research results transfered to therapy projects as fast as possible.

Original source
Gediminas Luksys, Matthias Fastenrath, David Coynel, Virginie Freytag, Leo Gschwind, Angela Heck, Frank Jessen, Wolfgang Maier, Annette Milnik, Steffi G. Riedel-Heller, Martin Scherer, Klara Spalek, Christian Vogler, Michael Wagner, Steffen Wolfsgruber, Andreas Papassotiropoulos, and Dominique J.-F. de Quervain
Computational dissection of human episodic memory reveals mental process-specific genetic profiles
PNAS (2015), doi: 10.1073/pnas.1500860112

Further information:
Prof. Dr. Dominique de Quervain, University of Basel, Transfaculty Research Platform Molecular and Cognitive Neurosciences, tel. +41 61 267 02 37, email: dominique.dequervain@unibas.ch

Olivia Poisson | Universität Basel
Further information:
http://www.unibas.ch

More articles from Studies and Analyses:

nachricht Researchers simplify tiny structures' construction drip by drip
12.11.2018 | Princeton University, Engineering School

nachricht Mandibular movement monitoring may help improve oral sleep apnea devices
06.11.2018 | Elsevier

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Massive impact crater from a kilometer-wide iron meteorite discovered in Greenland

15.11.2018 | Earth Sciences

When electric fields make spins swirl

15.11.2018 | Physics and Astronomy

Discovery of a cool super-Earth

15.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>