Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IU study examines how genes, gender and environment influence substance abuse

18.08.2014

Social integration, including strong family ties, can protect one's well-being and even reduce the impact high-risk genes have on health. Scientists call this phenomenon a gene-environment interaction. An Indiana University study focusing on substance abuse, however, found that a three-way interplay of gender, genetics and social integration produced the different outcomes for men and women.

The study looked at men and women with a genetic sensitivity to stressful situations. Strong family and community ties were protective for such men, reducing their risk of abusing alcohol and drugs or using tobacco; but for women with the same genetic sensitivity, the costs associated with strong social ties could outweigh the benefits.

Clinicians and researchers have known for decades that gender shapes the kinds of risks and protections people are exposed to in everyday life, causing men and women to experience different types of health problems. The study by medical sociologist Brea Perry is unique because it adds the genetic dimension.

"It is likely that gene-environment interactions may operate differently for men and women, perhaps because they experience some aspects of the social world in divergent ways," Perry said. "In families and communities, for example, women often bear more responsibility for developing and maintaining relationships, and do more of the care work that is required in those contexts. We cannot assume that a social environment that is favorable for men, and thus reduces the harmful impact of a risky genotype, is also beneficial for women, or vice versa."

She is discussing her findings at 8:30 a.m. Monday at the American Sociological Association's annual meeting in San Francisco.

Perry's study used data from the Collaborative Study on the Genetics of Alcoholism, a study funded by the National Institutes of Health to map genes associated with alcohol dependence and related patterns of substance abuse and behavior. The sample of participants in her analysis included 4,307 adults from 1,026 families. Some of the participants had substance dependence, but not all did. She targeted the GABRA2 gene, which is related to increased risk for substance use disorders through sensitivity to stressful or emotionally charged social environments.

Social integration can help those who struggle with substance abuse, particularly men who are in need of additional emotional support and strong bonds to keep them from engaging in excessive drinking or drug use. For women, ties to family and community are positive for most, but the demands of relationships may be overwhelming for women with a sensitivity to stress. According to Perry, these women would likely benefit from a stronger social services safety net, including programs that shift some of the responsibility for care work off their shoulders. Such programs might include government-subsidized child care or in-home health workers for those with ill or elderly relatives.

Research indicates that social and biological factors interact in very complex ways to shape health and well-being, and gender may complicate this picture even further. However, the potential impact of this kind of research on our understanding of how and why certain groups are more or less susceptible to physical and mental health problems is substantial.

"It is quite likely that any heritable health condition that is influenced by social factors, such as obesity, cardiovascular disease and depression, might exhibit gender-specific gene-environment interactions," Perry said.

But it also points to the complexity of disease and health behavior.

###

The study was supported by the Peter F. McManus Charitable Trust.

Perry can be reached at blperry@indiana.edu or 812-856-0447. For additional assistance, contact Tracy James at 812-855-0084 or traljame@iu.edu.

Brea Perry | Eurek Alert!

Further reports about: alcohol dependence factors families genes problems sensitivity stressful

More articles from Studies and Analyses:

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Oxygen loss in the coastal Baltic Sea is “unprecedentedly severe”
05.07.2018 | European Geosciences Union

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>