The 25 country report has led to the creation of the International Neuroblastoma Risk Group Classification System, with the results published in two papers in the Journal of Clinical Oncology today.
Professor Pearson, alongside co-author Professor Susan Cohn at the University of Chicago are extremely optimistic about improving standards of care for all neuroblastoma patients. Professor Andrew Pearson comments:
“This tailored strategy will hopefully replace the existing ‘one size fits all’ approach utilised across the world. It streamlines the process for identifying what stage the disease is at and how aggressive it is, and clearly identifies how much treatment each child should receive.”
“In this way, we hope that children with neuroblastoma will receive the best possible chance of a cure, keeping the level of treatment and the associated side-effects to a minimum.”
The new strategy will be used by the International Neuroblastoma Risk Group (INRG) which represents paediatric oncologists treating neuroblastoma patients treated in Europe, Japan, the USA, Canada, and Australia.
Survival rates overall for children with cancer have improved dramatically in recent years. However, more than half of children with neuroblastoma will present the aggressive, high-risk disease, which is more likely to relapse and is linked with a poor rate of recovery.
“How neuroblastoma attacks the body varies dramatically in each patient and, up until now, it has been difficult to accurately predict the progression of the disease. With these systems, we will be able to choose appropriate treatments based on the evidence of relevant risk factors.” Professor Pearson says.
Neuroblastoma, a cancer of the developing nervous system, is one of the most common types of childhood cancers, causing 15 per cent of all childhood cancer deaths in the UK. Its different forms vary in severity: while some cases in young children disappear with minimal treatment, cases in older children can be relentlessly aggressive. Identifying the form is therefore crucial in planning appropriate treatment.
Bethany Hankin was diagnosed with aggressive neuroblastoma aged 18 months. Now 3 years old and in remission, her mother Katie Hankin is eager to see better information for doctors:
“The harsh reality is that neuroblastoma is one of the most aggressive childhood cancers, yet receives very little attention. During Bethany’s first course of treatment, we had been told parts of her diagnosis, but not the exact status of her disease. Neuroblastoma is such an unpredictable disease, any research that helps doctors make a more informed diagnosis sooner can only be a blessing for families.”
This new research was funded by the William Guy Forbeck Research Foundation and Little Heroes Paediatric Cancer Research Foundation, and offers clearer direction for diagnosis and risk assessment for clinicians on a global level.
The first of the two papers proposes the International Neuroblastoma Risk Group (INRG) classification system. The paper focuses on the personalisation of treatment by classifying neuroblastoma based on 13 factors.
The second paper replaces the current four stage system of diagnosis of neuroblastoma based on a new International Neuroblastoma Risk Group Staging System (INRGSS.)
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
16.08.2018 | Life Sciences
16.08.2018 | Earth Sciences
16.08.2018 | Life Sciences