The research, published in the journal Proceedings of the National Academy of Sciences, USA and funded by a £72,000 grant from the British Lung Foundation, has found that the tumour suppressor gene, LIMD1, is responsible for protecting the body from developing lung cancer — paving the way for possible new treatments and early screening techniques.
Lead researcher Dr Tyson Sharp and his University of Nottingham team, together with US collaborator Dr Greg Longmore, set out to examine if loss of the LIMD1 gene correlated with lung cancer development.
The University of Nottingham team examined lung cancer tissue from patients with the disease and compared it to healthy lung tissue. They found that the LIMD1 gene was missing in the majority of lung cancer samples, indicating that the presence of the LIMD1 gene protects the body against lung cancer.
Dr Greg Longmore’s team in the USA supported these findings, using a mouse without the LMID1 gene which developed lung cancer.
Dr Sharp said: “The LIMD1 gene studied in this research is located on part of chromosome 3, called 3p21.
“Chromosome 3p21 is often deleted very early on in the development of lung cancer due to the toxic chemicals in cigarettes, which implies that inactivation of LIMD1 could be a particularly important event in early stages of lung cancer development.
“We are now going to extend these finding by developing LIMD1 as a novel prognostic tool for detection of early stage lung cancer.”
Lung cancer is the UK’s biggest cancer killer, claiming around 33,600 lives a year. Ninety per cent of cases are caused by smoking. At present lung cancer is often detected late, meaning that 80 per cent of patients die within a year of being diagnosed.
Dame Helena Shovelton, Chief Executive of the British Lung Foundation said: “This is very exciting research which could lead to the development of early screening techniques and treatments for lung cancer. We are very proud to have made this breakthrough possible”.
Emma Thorne | alfa
Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences