A joint study by UCLA and the University of Southern California has found that children whose mothers suffered from HG while carrying them were 3.6 times more likely to suffer from anxiety, bipolar disorder and depression in adulthood than individuals whose mothers did not have the condition. HG sends some 285,000 women to the hospital in the U.S. each year.
The study is published in the August 2011 issue of the Journal of Developmental Origins of Health and Disease.
Prior studies have found that children of women who experience nausea persisting beyond the first trimester of pregnancy have more attention and learning problems by age 12, said study co-author Marlena Fejzo, an assistant professor of hematology–oncology at the David Geffen School of Medicine at UCLA and an assistant professor of maternal and fetal medicine at the Keck School of Medicine of USC. And other studies have found that poor fetal nutrition, a frequent result of HG, can lead to poor health in adulthood.
"Even though hyperemesis gravidarum can be a form of starvation and dehydration in pregnancy, no studies prior to this have been done to determine the long-term effects it has on the exposed unborn child," Fejzo said.
HG often runs in families and in previous research, Fejzo and her colleagues found that women with a family history of the condition were up to 17 times more likely to suffer from it themselves.
The findings from the current study were based on surveys of women with HG who reported on the emotional and behavioral histories of their siblings. Of the 150 respondents, 55 had mothers who also suffered from the condition, so their siblings were exposed to HG in utero; 95 had mothers who didn't experience HG, and thus their siblings were not exposed. There was a total of 87 siblings from the exposed group (the "cases") and 172 from the non-exposed group (the "controls").
The researchers found that 16 percent of siblings from the exposed group had depression, compared with 3 percent from the non-exposed group; 8 percent from the exposed group were diagnosed with bipolar disorder, compared with 2 percent from the non-exposed group; and 7 percent from the exposed group suffered from anxiety in adulthood, compared with 2 percent from the non-exposed group.
"In all, among 17 diagnoses, 38 percent of the cases [those from the exposed group] are reported to have a psychological and/or behavioral disorder, as compared to 15 percent of controls," the researchers write. "In this study, adults exposed to HG in utero are significantly more likely to have a psychological and/or behavioral disorder than non-exposed adults."
These higher rates could stem from the mothers' prolonged malnutrition and dehydration during fetal brain development. And the anxiety and stress that are common during and after HG pregnancies may also play a part, the researchers said.
The researchers noted that the study has limitations. For instance, it was based on recall and self-reporting, which can lead to biased or incomplete responses, so the rates of diagnoses within each group should be treated with caution, they said.
Still, the very significant differences reported suggest that adults who were exposed to HG in utero could be at a nearly fourfold higher risk for lifelong neurobehavioral disorders in adulthood.
"HG is an understudied and undertreated condition of pregnancy that can result in not only short-term maternal physical and mental health problems but also potentially lifelong consequences to the exposed fetus," the researchers concluded.
The Intramural Research Program of the National Institute of Child Health and Human Development funded this study.
Additional study co-authors were Andrew Bray and Frederic Schoenberg of UCLA; Patrick Mullin and T. Murphy Goodwin of USC; Kimber W. MacGibbon of the Hyperemesis Education and Research Foundation; and Roberto Romero of the Department of Health and Human Services.
Please contact Fejzo at firstname.lastname@example.org to participate in the HG research.
The David Geffen School of Medicine at UCLA ranks among the nation's elite medical schools, producing doctors and researchers whose contributions have led to major breakthroughs in health care. With more than 2,000 full-time faculty members, nearly 1,300 residents, more than 750 medical students and almost 400 Ph.D. candidates, the medical school consistently ranks among the top institutions in National Institutes of Health and overall research funding.
For more news, visit UCLA Newsroom and UCLA News|Week and follow us on Twitter.
Enrique Rivero | EurekAlert!
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
16.08.2018 | Life Sciences
16.08.2018 | Earth Sciences
16.08.2018 | Life Sciences