In the study, the Icelandic company Decode Genetics together with Helmholtz Zentrum München and a number of other international research institutes performed a genome-wide association scan of more than 50,000 test persons. The researchers found several sequence variants associated with asthma.
“Two of the detected sequence variants are of significance for a biochemical pathway in the interleukin-1 cluster,” explained Dr. Matthias Wjst, who was one of the initiators of the study at the Institute of Inhalation Biology of Helmholtz Zentrum München. This finding confirms the results of a research group at Helmholtz Zentrum München from 2004, which showed that the IL-1 gene cluster is associated with asthma.
“We do not yet know what mechanisms underlie the effect of these sequence variants on the inflammatory cells,” Dr. Wjst said, “but these findings give us new starting points for a better understanding of the various hypotheses of allergic inflammation.”
Allergic and respiratory diseases are among the key research areas of Helmholtz Zentrum München, which is dedicated to disease research at the interface of genetics, lifestyle and environmental influences. The center’s research goal is to elucidate biological mechanisms to achieve a better understanding of the disease process and thus to develop therapies and prevention strategies. Neuherberg, January 8, 2009D. Gudbjartson et al.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. DOI 10.1038/ng.323
Michael van den Heuvel | alfa
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Oxygen loss in the coastal Baltic Sea is “unprecedentedly severe”
05.07.2018 | European Geosciences Union
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
17.07.2018 | Power and Electrical Engineering
17.07.2018 | Life Sciences
16.07.2018 | Physics and Astronomy