The study is published in the June 20, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
For the study, 159 people with Parkinson’s disease randomly assigned to deep brain stimulation of the globus pallidus interna (GPi) or subthalamic nucleus (STN) of the brain were followed for three years. Participants reported motor symptoms in a diary for 30 minutes every half hour for two days before each of the six study visits. Medication use was allowed in the study.
“Past studies have had mixed results about which area of the brain benefits the most from deep brain stimulation,” said study author Frances M. Weaver, PhD, with Hines Veterans Administration Hospital and Loyola University Stritch School of Medicine in Maywood, Ill. “In our study, deep brain stimulation of both areas improved motor symptoms by 32 percent on average over the course of three years. However, deep brain stimulation of the GPi region of the brain was associated with a slower decline in thinking skills. More research will help us to find out whether medication or the deep brain stimulation was responsible for these differences.”
The study does have one major limitation, according to accompanying editorial author Michele Tagliati, MD, with Cedars-Sinai Medical Center in Los Angeles and a Fellow of the American Academy of Neurology. “A fairly large amount, or about 50 percent, of the initial participants could not be observed at three years due to the original study design and timeline. However, these data provide more reliable evidence that the improvement of motor symptoms of Parkinson’s disease by deep brain stimulation remains stable over the long term regardless of the area in the brain in which the deep brain stimulation occurs,” said Tagliati.
The study was supported by the Cooperative Studies Program, the Department of Veterans Affairs Office of Research and Development and the National Institute of Neurological Disorders and Stroke with additional funding from Medtronic Neurological, Inc.
To learn more about Parkinson’s disease, visit http://www.aan.com/patients.
The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com
Rachel L. Seroka | American Academy of Neurology
Risk of infection with COVID-19 from singing: First results of aerosol study with the Bavarian Radio Chorus
03.07.2020 | Klinikum der Universität München
Age research: A low level of the stress hormone cortisol contributes to the ageing process
01.07.2020 | Universität des Saarlandes
Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.
Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....
Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.
Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...
A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...
Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"
The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...
With an X-ray experiment at the European Synchrotron ESRF in Grenoble (France), Empa researchers were able to demonstrate how well their real-time acoustic monitoring of laser weld seams works. With almost 90 percent reliability, they detected the formation of unwanted pores that impair the quality of weld seams. Thanks to a special evaluation method based on artificial intelligence (AI), the detection process is completed in just 70 milliseconds.
Laser welding is a process suitable for joining metals and thermoplastics. It has become particularly well established in highly automated production, for...
02.07.2020 | Event News
19.05.2020 | Event News
07.04.2020 | Event News
03.07.2020 | Life Sciences
03.07.2020 | Studies and Analyses
03.07.2020 | Power and Electrical Engineering