Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Childhood virus infection linked to prolonged seizures with fever

14.06.2012
One-third of febrile seizures associated with roseola virus

New research shows that human herpesviruses (HHV)-6B and HHV-7, commonly know as roseola virus), account for one third of febrile status epilepticus (FSE) cases. Results of the FEBSTAT prospective study now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE), suggest that HHV-6B may be involved in the development of epilepsy and further research is urgently needed.

FEBSTAT is a multi-center study of the consequences of FSE, designed to identify the factors that increase the risk of injury to the hippocampus, an area of the brain responsible for long-term memory and implicated in the development of temporal lobe epilepsy. The FEBSTAT study is funded by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH).

According to previous research, up to 5% of children under the age of five have febrile seizures, making it the most common type of seizure, with peak incidence at age 2. While brief or simple febrile seizures are most common, 5% - 8% of cases are prolonged and meet the criteria for status epilepticus (SE)—a critical condition where a persistent seizure lasts more than 30 minutes. Experts suggest that FSE accounts for 5% of FS; however, FSE accounts for 25% of all childhood SE and for more than 70% of SE cases that occur in the second year of life. FSE is associated with increased epilepsy risk, particularly temporal lobe epilepsy (TLE).

"One aim of the FEBSTAT study is to determine the frequency of HHV-6A, HHV-6B, and HHV-7 as a cause of FSE and whether infection with any of these herpesviruses increases the risk of brain injury and epilepsy," said lead author Dr. Leon Epstein a, pediatric neurologist at the Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago.

The team enrolled 199 children between the ages of 1 month and 5 years, who presented with FSE and received an assessment for herpesvirus infection within 72 hours of the episode. Viremia was detected using polymerase chain reaction (PCR) that identified the presence of HHV-6A, HHV-6B or HHV-7A DNA and RNA. In conjunction with PCR results, researchers used antibody titers to determine if the infection was a primary or reactivated herpesvirus.

Findings indicate that approximately one third of children with FSE had HHV-6 or HHV-7 viremia. HHV-6B viremia was detected in 32% of pediatric participants, with 38 and 16 children having primary and reactivated infection, respectively. Researchers found that 7% of children had HHV-7 viremia at baseline and 2 children had HHV-6/7 primary co-infection. There were no apparent differences in age, illness type, fever, seizure structures, or acute imagining abnormalities in children with or without one of the herpesviruses.

FEBSTAT researchers will continue to follow the 199 children involved in the study, expecting up to 40% of this pediatric population to develop TLE. The FEBSTAT study will determine whether there is an association between prolonged febrile seizures caused by HHV-6B viremia and the development of TLE. The current study adds to evidence from previous research by Donati et al. and by Fotheringham et al who detected HHV-6 in brain samples of patients with TLE.

"TLE could take 8 to 11 years to develop following an episode of FSE, so more time is needed before the role of HHV-6B is fully understood," concludes Dr. Epstein. "If the FEBSTAT study finds that FSE caused by HHV-6B leads to TLE, this insight would provide a basis for clinical trials of antiviral and anti-inflammatory therapies to prevent TLE."

This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact healthnews@wiley.com.

Full citation: "Human herpesvirus 6 and 7 in febrile status epilepticus: The FEBSTAT study." Leon G. Epstein, Shlomo Shinnar, Dale C. Hesdorffer, Douglas R. Nordli, Aaliyah Hamidullah, Emma K. T. Benn, John M. Pellock, L. Matthew Frank, Darrell V Lewis, Solomon L. Moshe, Ruth C. Shinnar, Shumei Sun and the FEBSTAT study team. Epilepsia; Published Online: June 14, 2012 (DOI: 10.1111/j.1528-1167.2012.03542.x).

URL upon publication: http://doi.wiley.com/10.1111/j.1528-1167.2012.03542.x

Author contact: Media wishing to speak with Dr. Epstein may contact Julie Pesch with Ann & Robert H. Lurie Children's Hospital of Chicago at jpesch@luriechildrens.org or at 312-227-4261.

Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.

The International League Against Epilepsy (ILAE) is the world's preeminent association of physicians and health professionals working toward a world where no person's life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy.

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | EurekAlert!
Further information:
http://www.wiley.com

Further reports about: Epilepsia Epilepsy FEBSTAT FSE HHV-6 HHV-6B HHV-7 ILAE Online Broker PCR TLE health professionals

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>