"These results are especially interesting for rehabilitation therapy for people who've had strokes or other issues," said study author Nicolas Langer, MSc, with the University of Zurich in Switzerland. "One type of therapy restrains the unaffected, or "good," arm to strengthen the affected arm and help the brain learn new pathways. This study shows that there are both positive and negative effects of this type of treatment."
For the study, researchers examined 10 right-handed people with an injury of the upper right arm that required a sling for at least 14 days. The entire right arm and hand were restricted to little or no movement during the study period. As a result, participants used their non-dominant left hand for daily activities such as washing, using a toothbrush, eating or writing. None of the people in the study had a brain injury, psychiatric disease or nerve injury.
The group underwent two MRI brain scans, the first within two days of the injury and the second within 16 days of wearing the cast or sling. The scans measured the amount of gray and white matter in the brain. Participants' motor skills, including arm-hand movements and wrist-finger speed, were also tested.
The study found that amount of gray and white matter in the left side of the brain decreased up to ten percent, while the amount of gray and white matter in the right side of the brain increased in size.
"We also saw improved motor skills in the left, non-injured hand, which directly related to an increase in thickness in the right side of the brain," said Langer. "These structural changes in the brain are associated with skill transfer from the right hand to the left hand."
Langer noted that the study did not look at whether the decreases would be permanent.
"Further studies should examine whether using a restraint for stroke patients is really a necessity for improving arm and hand movement," he said. "Our results also support the current trauma surgery guidelines stating that an injured arm or leg should be immobilized 'as short as possible, as long as necessary.'"
The study was supported by the National Center of Competence in Research and the Swiss National Science Foundation.
The American Academy of Neurology, an association of 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson's disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com or find us on Facebook, Twitter, Google+ and YouTube.
Rachel Seroka | American Academy of Neurology
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