The combined effects of chemotherapy and endocrine therapy may increase the risk of bone fractures in breast cancer survivors.
In a study scheduled for publication in the April issue of the Archives of Physical Medicine and Rehabilitation, researchers from the Oregon Health & Science University Knight Cancer Institute, Portland, asked post-menopausal breast cancer survivors whether they had fallen in the past year and then tracked their falls over a six-month study period. They found evidence that women who have survived breast cancer may fall more often than their peers.
"Our study is the first to consider how breast cancer treatment may increase fall risk by using a comprehensive set of objective measures of fall risk and by exploring mediators of the treatment-falls relationship," commented Kerri M. Winters-Stone, PhD, Associate Professor and Associate Scientist, Oregon Health & Science University, School of Nursing and a member of the Knight Cancer Institute. "Our findings suggest that recently treated postmenopausal breast cancer survivors have higher rates of falling compared with population averages for community-dwelling older adults. Balance disturbances may explain how treatment could have contributed to falls in breast cancer survivors."
Investigators found that 58% of breast cancer survivors had experienced a fall in the previous year and almost half (47%) fell within 6 months after joining the study, a rate nearly double the 25% to 30% annual fall rate reported for community-dwelling older adults over 65 years of age.
Researchers measured a comprehensive set of neuromuscular and balance characteristics known to be associated with falls in 59 study participants. They found that only balance discriminated breast cancer survivors who fell from those who did not. The study findings also suggest that the balance problems may have been related to changes in the vestibular system that were associated with chemotherapy treatment.
Professor Winters-Stone stated, "Falls in breast cancer survivors are understudied and deserve more attention, particularly in light of the increase in fractures after breast cancer treatment and the relationship of falls to fractures. Our findings add to growing evidence that fall risk is increased in breast cancer survivors and that vestibular function may underpin associations between breast cancer treatment and falls."
The article is "Identifying Factors Associated With Falls in Postmenopausal Breast Cancer Survivors: A Multi-Disciplinary Approach" by Kerri M. Winters-Stone, PhD, Britta Torgrimson, PhD, Fay Horak, PhD, PT, Alvin Eisner, PhD, Lillian Nail, PhD, RN, Michael C. Leo, PhD, Steve Chui, MD, and Shiuh-Wen Luoh, MD. It will appear in Archives of Physical Medicine and Rehabilitation, Volume 92, Issue 4 (April 2011), published by Elsevier. doi:10.1016/j.apmr.2010.10.039
Nancy Burns | EurekAlert!
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Oxygen loss in the coastal Baltic Sea is “unprecedentedly severe”
05.07.2018 | European Geosciences Union
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
16.07.2018 | Physics and Astronomy
16.07.2018 | Life Sciences
16.07.2018 | Earth Sciences