Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The biggest loser: Maternal obesity puts a load on her offspring that lasts a lifetime

10.02.2010
Duke researchers report in the FASEB Journal that maternal obesity dramatically increases the risk of diseases related to inflammation gone awry: heart disease, stroke and more

As if there are not enough reasons for obese people to lose weight, a new research report published online in The FASEB Journal, adds several more. In a study involving rats, researchers from Duke University found that obesity in mothers causes cellular programming in utero that predisposes offspring to inflammation-related disorders (such as Alzheimer's, Parkinson's, type 2 diabetes, stroke, heart disease, and more) from the day that they are born, regardless of whether or not the offspring are obese themselves.

"We hope these data will eventually lead to treatments for obesity-associated problems, by the identification of novel targets within the immune system," said Staci D. Bilbo, Ph.D., co-author of the study, from the Department of Psychology and Neuroscience at Duke University in Durham, N.C. "Our hope is also that these data will lead people to consider the consequences of their dietary intakes not only for their own health, but also for their children's health, and potentially even their grandchildren's health."

To make this discovery, Bilbo and colleagues placed rats on one of three diets (low-fat, high-saturated fat, and high-trans fat) four weeks prior to mating and throughout pregnancy and lactation. The high-fat diets rendered the mice clinically obese. Researchers analyzed the brains of the newborn pups after challenge by inflammatory stimuli. Offspring born to mothers on the high-fat diets showed increased immune cell activation and release of injurious products (cytokines). This overshoot was already apparent on the day after birth. When the scientists continued to analyze the pup brains through their juvenile and adult years, and even after the rats were put on healthy low-fat diets, this hyper-response to inflammation remained dramatically increased compared to rats born to normal-weight mothers.

"If there ever was a maternal hex, obesity might be it," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and as it turns out, even after the weight comes off, the biggest loser isn't a mother, but her child."

Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB). The journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information. FASEB is composed of 23 societies with more than 90,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of biomedical and life scientists to improve-through their research-the health, well-being and productivity of all people. Its mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Staci D. Bilbo and Verne Tsang. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J. doi:10.1096/fj.09-144014 ; http://www.fasebj.org/cgi/content/abstract/fj.09-144014v1

Cody Mooneyhan | EurekAlert!
Further information:
http://www.faseb.org
http://www.fasebj.org

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>