Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A study of 377,000 sheds light on the role played by the genome in eczema

21.10.2015

The largest genetic study of atopic dermatitis ever performed permitted a team of international researchers to identify ten previously unknown genetic variations that contribute to the development of the condition. The researchers also found evidence of genetic overlap between atopic dermatitis and other illnesses, including inflammatory bowel disease. The results was published in Nature Genetics online on October 19.

Atopic dermatitis, a type of eczema, afflicts approximately one out of every five children and one out of every twelve adults. Though knowledge of the genome is crucial to assessing the likelihood that an individual will develop atopic dermatitis, most genes responsible for the condition have not yet been discovered.


A study of 377,000 sheds light on the role played by the genome in eczema

University of Gothenburg

The team of international researchers that conducted the largest genetic study of atopic dermatitis to this point pooled data obtained from 377,000 subjects in 40 different projects around the world.

31 currently known

“We identified ten new genetic variations, making a total of 31 that are currently known to be associated with atopic dermatitis,” says Bo Jacobsson, a professor at Sahlgrenska Academy who was a member of the team. “Of particular interest is that each of the new ones has a role to play in regulation of the immune system.”

The researchers found evidence of genetic overlap between atopic dermatitis and other illnesses, including inflammatory bowel disease.

Additional treatment

“While the new variations contribute in only a small way to the risk of developing atopic dermatitis, knowing about them will raise our awareness about the mechanisms of the various diseases,” Professor Jacobsson says. “Our ultimate hope is that additional treatment methods will emerge as a result.”

Although the importance of genetic factors in the pathogenesis of atopic dermatitis had already been established, the sheer size of this study allowed researchers to fine tune their understanding and obtain more information about the ways that autoimmune mechanisms run amok as the disease develops.

Large study

A total of 21,399 cases of European, African, Japanese and Latino ancestry were first compared in 22 different studies with 95,464 controls. The findings were then replicated in 18 studies of 32,059 cases and 228,628 controls.

“Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis” was published in Nature Genetics online on October 19.

For additional information, you are welcome to contact:
Bo Jacobsson, Professor, Sahlgrenska Academy, University of Gothenburg
bo.jacobsson@obgyn.gu.se

Weitere Informationen:

http://www.gu.se/english/about_the_university/news-calendar/News_detail//a-study...

Henrik Axlid | idw - Informationsdienst Wissenschaft

More articles from Studies and Analyses:

nachricht Graphene gives a tremendous boost to future terahertz cameras
16.04.2019 | ICFO-The Institute of Photonic Sciences

nachricht Mount Kilimanjaro: Ecosystems in Global Change
28.03.2019 | Julius-Maximilians-Universität Würzburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>