Sunlight and serotonin underlie seasonal mood disorders

Authors of a research letter in this week’s issue of THE LANCET provide further evidence that the effect of sunlight on neurotransmitters in the brain plays a significant role in seasonal mood disorders.

The success of phototherapy (ultraviolet light therapy to stimulate brain neurotransmitter activity) and drugs that prevent the reuptake of the neurotransmitter serotonin have suggested that serotonin itself has a role in the development of seasonal depression. However, concentrations of serotonin and other neurotransmitters including dopamine and norepinephrine are normal in the cerebrospinal fluid of patients with seasonal affective disorder.

Gavin Lambert from the Baker Research Institute, Melbourne, Australia, and colleagues investigated whether measurement of serotonin concentrations from blood vessels draining the brain—a more accurate way of measuring serotonin concentrations in the brain than by analysis of cerebrospinal fluid—might provide stronger evidence for the role of serotonin in mood disorders. The investigators took blood samples from internal jugular veins in 101 healthy men to assess the relation between serotonin concentration and weather conditions and season.

The turnover of serotonin by the brain was lowest in winter, and the rate of production of serotonin by the brain was directly related to the prevailing duration of bright sunlight.

Gavin Lambert comments: “Our observations suggest that the prevailing amount of sunlight affects brain serotonergic activity, and thus underlies mood seasonality and seasonal affective disorder, although we do not know whether patients predisposed to affective disorders are affected by environmental factors in the same way as our healthy volunteers.”

Media Contact

Richard Lane alfa

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Creating good friction: Pitt engineers aim to make floors less slippery

Swanson School collaborators Kurt Beschorner and Tevis Jacobs will use a NIOSH award to measure floor-surface topography and create a predictive model of friction. Friction is the resistance to motion…

Synthetic tissue can repair hearts, muscles, and vocal cords

Scientists from McGill University develop new biomaterial for wound repair. Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the…

Constraining quantum measurement

The quantum world and our everyday world are very different places. In a publication that appeared as the “Editor’s Suggestion” in Physical Review A this week, UvA physicists Jasper van…

Partners & Sponsors