Health and Medicine

Sperm go slow without a crucial protein.

The discovery of a protein that is crucial to sperm swimming in mice could lead to new male or female contraceptives or fertility treatments.

The protein forms a channel through the membrane of the sperm tail. It controls the inflow of calcium ions that trigger swimming.

All humans have the gene that encodes the channel, but it is switched on only in sperm cells. This would lessen the risk of side-effects from any channel-blo

A new way to find genes and map disease.

A new technique should aid the hunt for genes in the human genome sequence. The method, which tracks only switched-on genes in cells, will help researchers to distinguish between diseased and normal tissues, and could point the way to new treatments.

Andrew Simpson, of the Ludwig Institute for Cancer Research in Sao Paulo, Brazil, and colleagues have produced a whopping 700,000 DNA tags, representing the genes that are active in 24 no

Mouse studies emphasize children’s cancer risk from sunburn.

Serious sunburn in childhood may raise the risk of developing the deadliest form of skin cancer as an adult, research in mice suggests 1 . The experiments could lead to a better understanding of malignant melanoma and of how and when to protect ourselves from the sun.

“I have my kids wear hats and put sunscreen on like crazy now,” says the study’s leader Glenn Merlino, of the National Cancer Institu

A virus that exploits a gene defect common to cancer cells and selectively kills them may offer a new avenue for therapy, suggest researchers in Nature.

The gene p53 is mutated in about half of all human cancers (an event directly implicated in tumour progression) so a way of killing such cells offers the attractive possibility of treating multiple cancer types with one drug. The human adeno-associated virus (AAV) selectively induces cell death in p53-defective cells, Peter Beard and his co