Identified a molecule that increases the risk of cardiac insufficiency
The research project, published in the journal Hypertension, is part of a project of the “Red Europea de Excelencia en Hipertensión y Enfermedades Cardiovasculares” [European Network of Excellence in Hypertension and Cardiovascular Diseases], in which research groups from Belgium, the Netherlands, Italy, Great Britain, France, Germany, Finland and Poland are all participating. The project also forms part of the “Red Española de Investigación de las Enfermedades Cardiovasculares” [Spanish Network for Research on Cardiovascular Diseases].
Today, cardiac insufficiency affects more than 1,250,000 Spanish men and women over the age of 45. More than half of these people have a life expectancy of less than five years. The accumulation of fibrosis in the heart has been proven to have a significant influence on the development of cardiac insufficiency among patients with chronic heart disease.
New methods for treating patients with heart disease
The research team from the CIMA analyzed the expression of Llysyl oxidase, an enzyme which regulates the amount of fibrous tissue in cardiac muscle. “By means of molecular and histological methods, we have found that the cardiac muscle in patients with cardiac insufficiency contains an excess of this enzyme as well as collagen fiber (which it produces). These factors are associated with the deterioration of cardiac functions,” explained Dr. Begoña López, Lead Researcher of the project.
According to the researchers, this project shows that some drugs prescribed for patients with cardiac insufficiency do not actually inhibit the enzyme lysyl oxidase, nor do they reduce fibrosis or improve heart functions. Other drugs however, which are less commonly used, do have these beneficial qualities. “Our work opens new possibilities for treating patients with heart disease through the inhibition of the enzyme. The development of cardiac insufficiency could thus be impeded,” said Begoña López.
Alle Nachrichten aus der Kategorie: Health and Medicine
This subject area encompasses research and studies in the field of human medicine.
Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.
Alien species to increase by 36% worldwide by 2050
The number of alien (non-native) species, particularly insects, arthropods and birds, is expected to increase globally by 36% by the middle of this century, compared to 2005, finds new research…
Geothermal energy: Fraunhofer IEG operates simulator for drilling at depths up to 5,000 meters
To tap into geothermal reservoirs, boreholes must be drilled deeply into the earth’s crust. Due to the extreme pressures and temperatures involved, this is expensive and time consuming. A research…