High-risk carotid artery plaque formation is increased in older COPD patients

“We know that COPD is a risk factor for ischemic stroke, and that certain components of carotid artery plaques such as intraplaque hemorrhage and lipid core increase the risk of ischemic events, but plaque composition in patients with COPD has not been examined,” said researcher Bruno H.C. Stricker, MD, PhD, professor of pharmaco-epidemiology at the Erasmus Medical Center in Rotterdam, the Netherlands.

“In our study, carotid artery wall thickening was increased twofold in older COPD patients compared with controls with normal lung function, and COPD was an independent predictor of the presence of plaques with a lipid core, which are more prone to rupture.”

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The cross-sectional study, part of the Rotterdam Study, an ongoing population-based cohort study examining the occurrence of and risk factors for chronic diseases in subjects aged 55 years and older, involved 253 COPD patients and 920 controls. COPD was confirmed by spirometry. Subjects with carotid wall thickening (intima-media thickness ¡Ý 2.5 mm) on ultrasonography underwent high-resolution magnetic resonance imaging (MRI) to characterize carotid plaques.

Subjects with COPD had a twofold increased risk (odds ratio 2.0, 95%CI 1.44-2.85, p

“Clinicians should be aware that COPD patients are at increased risk for asymptomatic carotid atherosclerosis and that COPD might lead to vulnerable plaques by inducing or aggravating the presence of plaques with a lipid core,” said Dr. Stricker.

The study had a few limitations, including the study's cross-sectional design, which doesn't allow causal associations between COPD and carotid plaques to be inferred, and the lack of computed tomography confirmation of emphysema

“The results of our study provide new insights into the relationship between COPD and the increased risk for stroke seen in these patients,” concluded Dr. Stricker. “Understanding the underlying risk factors for stroke in COPD patients can help identify those at high risk and lead to the development of more personalized preventive treatment strategies targeting this devastating complication.”

About the American Journal of Respiratory and Critical Care Medicine:

With an impact factor of 11.080, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields. Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.

Media Contact

Nathaniel Dunford EurekAlert!

Weitere Informationen:

http://www.thoracic.org

Alle Nachrichten aus der Kategorie: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Cyanobacteria: Small Candidates …

… as Great Hopes for Medicine and Biotechnology In the coming years, scientists at the Chair of Technical Biochemistry at TU Dresden will work on the genomic investigation of previously…

Do the twist: Making two-dimensional quantum materials using curved surfaces

Scientists at the University of Wisconsin-Madison have discovered a way to control the growth of twisting, microscopic spirals of materials just one atom thick. The continuously twisting stacks of two-dimensional…

Big-hearted corvids

Social life as a driving factor of birds’ generosity. Ravens, crows, magpies and their relatives are known for their exceptional intelligence, which allows them to solve complex problems, use tools…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close